Gene description for Ctnna1
Gene name catenin (cadherin associated protein), alpha 1
Gene symbol Ctnna1
Other names/aliases 2010010M04Rik
AA517462
AI988031
Catna1
Species Mus musculus
 Database cross references - Ctnna1
ExoCarta ExoCarta_12385
Vesiclepedia VP_12385
Entrez Gene 12385
UniProt P26231  
 Ctnna1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctnna1
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IBA
    beta-catenin binding GO:0008013 IEA
    beta-catenin binding GO:0008013 ISO
    vinculin binding GO:0017166 IEA
    vinculin binding GO:0017166 ISO
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
    gamma-catenin binding GO:0045295 IEA
    gamma-catenin binding GO:0045295 ISO
    cadherin binding GO:0045296 IEA
    cadherin binding GO:0045296 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
Biological Process
    ovarian follicle development GO:0001541 IEA
    apoptotic process GO:0006915 IMP
    establishment or maintenance of cell polarity GO:0007163 IMP
    smoothened signaling pathway GO:0007224 IGI
    integrin-mediated signaling pathway GO:0007229 IMP
    neuroblast proliferation GO:0007405 IGI
    neuroblast proliferation GO:0007405 IMP
    negative regulation of neuroblast proliferation GO:0007406 IGI
    negative regulation of neuroblast proliferation GO:0007406 IMP
    protein localization GO:0008104 IMP
    male gonad development GO:0008584 IEA
    gap junction assembly GO:0016264 IEA
    gap junction assembly GO:0016264 ISO
    cell migration GO:0016477 IBA
    axon regeneration GO:0031103 IEA
    regulation of cell population proliferation GO:0042127 IGI
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    apical junction assembly GO:0043297 IMP
    response to estrogen GO:0043627 IEA
    positive regulation of smoothened signaling pathway GO:0045880 IGI
    cell motility GO:0048870 IMP
    cellular response to indole-3-methanol GO:0071681 IEA
    cellular response to indole-3-methanol GO:0071681 ISO
    epithelial cell-cell adhesion GO:0090136 IMP
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IMP
    cell-cell adhesion GO:0098609 IBA
    negative regulation of protein localization to nucleus GO:1900181 IMP
    negative regulation of cell motility GO:2000146 IMP
    negative regulation of integrin-mediated signaling pathway GO:2001045 IMP
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IMP
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IMP
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    acrosomal vesicle GO:0001669 ISO
    nucleus GO:0005634 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    adherens junction GO:0005912 ISO
    zonula adherens GO:0005915 IDA
    intercalated disc GO:0014704 IDA
    actin cytoskeleton GO:0015629 IEA
    catenin complex GO:0016342 IBA
    catenin complex GO:0016342 IEA
    catenin complex GO:0016342 ISO
    flotillin complex GO:0016600 IDA
    lamellipodium GO:0030027 IDA
    cell junction GO:0030054 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ctnna1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctnna1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sptbn1 20742
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Fxr1 14359
Affinity Capture-MS Mus musculus
4 Ctnnb1 12387
Affinity Capture-Western Mus musculus
5 Tmem173  
Proximity Label-MS Mus musculus
6 Pcp2  
Affinity Capture-Western Mus musculus
7 Ptprq  
Affinity Capture-Western Mus musculus
8 Eed  
Affinity Capture-MS Mus musculus
9 Sec23a  
Co-fractionation Mus musculus
10 Jup 16480
Two-hybrid Mus musculus
Co-fractionation Mus musculus
11 Pex5l  
Affinity Capture-MS Mus musculus
12 Chaf1a  
Affinity Capture-MS Mus musculus
13 Unk  
Affinity Capture-RNA Mus musculus
14 Fmn1  
Affinity Capture-Western Mus musculus
15 Fancd2  
Affinity Capture-MS Mus musculus
16 Cdh1 12550
Affinity Capture-Western Mus musculus
17 Apc  
Phenotypic Suppression Mus musculus
18 Ctnnd1 12388
Co-fractionation Mus musculus
19 Tjp1  
Co-fractionation Mus musculus
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