Gene description for ACSM1
Gene name acyl-CoA synthetase medium-chain family member 1
Gene symbol ACSM1
Other names/aliases BUCS1
MACS1
Species Homo sapiens
 Database cross references - ACSM1
ExoCarta ExoCarta_116285
Vesiclepedia VP_116285
Entrez Gene 116285
HGNC 18049
MIM 614357
UniProt Q08AH1  
 ACSM1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ACSM1
Molecular Function
    fatty-acyl-CoA synthase activity GO:0004321 IBA
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    GTP binding GO:0005525 IEA
    fatty acid ligase activity GO:0015645 IBA
    CoA-ligase activity GO:0016405 TAS
    benzoate-CoA ligase activity GO:0018858 IDA
    medium-chain fatty acid-CoA ligase activity GO:0031956 IDA
    metal ion binding GO:0046872 IEA
    decanoate-CoA ligase activity GO:0102391 IDA
Biological Process
    long-chain fatty acid metabolic process GO:0001676 IEA
    fatty acid biosynthetic process GO:0006633 IBA
    acyl-CoA metabolic process GO:0006637 IBA
    xenobiotic metabolic process GO:0006805 TAS
    energy derivation by oxidation of organic compounds GO:0015980 NAS
    benzoate metabolic process GO:0018874 NAS
    fatty acid oxidation GO:0019395 NAS
    butyrate metabolic process GO:0019605 NAS
    cholesterol homeostasis GO:0042632 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified ACSM1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ACSM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRC1 9055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MAGEA2B  
Two-hybrid Homo sapiens
3 SLC22A16 85413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MAGEA2  
Two-hybrid Homo sapiens
5 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MTUS2 23281
Two-hybrid Homo sapiens
7 LDLR 3949
Positive Genetic Homo sapiens
8 CMTM5  
Two-hybrid Homo sapiens
9 GBP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here