Gene description for Aplp1
Gene name amyloid beta (A4) precursor-like protein 1
Gene symbol Aplp1
Other names/aliases -
Species Mus musculus
 Database cross references - Aplp1
ExoCarta ExoCarta_11803
Vesiclepedia VP_11803
Entrez Gene 11803
UniProt Q03157  
 Aplp1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Aplp1
Molecular Function
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    alpha-2A adrenergic receptor binding GO:0031694 IBA
    alpha-2A adrenergic receptor binding GO:0031694 IEA
    alpha-2A adrenergic receptor binding GO:0031694 ISO
    alpha-2B adrenergic receptor binding GO:0031695 IBA
    alpha-2B adrenergic receptor binding GO:0031695 IEA
    alpha-2B adrenergic receptor binding GO:0031695 ISO
    alpha-2C adrenergic receptor binding GO:0031696 IBA
    alpha-2C adrenergic receptor binding GO:0031696 IEA
    alpha-2C adrenergic receptor binding GO:0031696 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    transition metal ion binding GO:0046914 IEA
Biological Process
    regulation of translation GO:0006417 IDA
    endocytosis GO:0006897 IEA
    apoptotic process GO:0006915 IEA
    cell adhesion GO:0007155 IEA
    axonogenesis GO:0007409 IBA
    central nervous system development GO:0007417 IBA
    extracellular matrix organization GO:0030198 IGI
    forebrain development GO:0030900 IGI
    cellular response to norepinephrine stimulus GO:0071874 IEA
    cellular response to norepinephrine stimulus GO:0071874 ISO
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 IEA
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 ISO
    cytosolic mRNA polyadenylation GO:0180011 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Aplp1 in sEVs
1
Experiment ID 210
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aplp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 App 11820
Affinity Capture-MS Mus musculus
2 Spon1 233744
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Aplp1 is involved
No pathways found





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