Gene description for TRIM40
Gene name tripartite motif containing 40
Gene symbol TRIM40
Other names/aliases RNF35
Species Homo sapiens
 Database cross references - TRIM40
ExoCarta ExoCarta_135644
Vesiclepedia VP_135644
Entrez Gene 135644
HGNC 18736
UniProt Q6P9F5  
 TRIM40 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TRIM40
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    negative regulation of cell growth GO:0030308 IEA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of protein catabolic process GO:0042177 IDA
    innate immune response GO:0045087 IBA
    protein neddylation GO:0045116 IDA
    negative regulation of protein localization to nucleus GO:1900181 IDA
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 NAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    IkappaB kinase complex GO:0008385 IDA
 Experiment description of studies that identified TRIM40 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TRIM40
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 MAVS 57506
Affinity Capture-Western Homo sapiens
3 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 IFIH1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
5 LGR4 55366
Affinity Capture-MS Homo sapiens
6 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 NLRP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 CHUK 1147
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 DDX58 23586
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM40 is involved
No pathways found





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