Gene description for H1f0
Gene name H1 histone family, member 0
Gene symbol H1f0
Other names/aliases D130017D06Rik
H1(0)
H1fv
Species Mus musculus
 Database cross references - H1f0
ExoCarta ExoCarta_14958
Vesiclepedia VP_14958
Entrez Gene 14958
UniProt P10922  
 H1f0 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for H1f0
Molecular Function
    DNA binding GO:0003677 EXP
    minor groove of adenine-thymine-rich DNA binding GO:0003680 IMP
    double-stranded DNA binding GO:0003690 IBA
    double-stranded DNA binding GO:0003690 IMP
    structural constituent of chromatin GO:0030527 IEA
    chromatin DNA binding GO:0031490 IEA
    chromatin DNA binding GO:0031490 ISO
    nucleosome binding GO:0031491 IEA
    nucleosome binding GO:0031491 ISO
    nucleosomal DNA binding GO:0031492 IBA
Biological Process
    nucleosome assembly GO:0006334 IEA
    chromosome condensation GO:0030261 IBA
    heterochromatin formation GO:0031507 IEA
    heterochromatin formation GO:0031507 ISO
    negative regulation of DNA recombination GO:0045910 IBA
    positive regulation of transcription regulatory region DNA binding GO:2000679 ISO
Subcellular Localization
    chromatin GO:0000785 ISO
    nucleosome GO:0000786 IEA
    euchromatin GO:0000791 IEA
    euchromatin GO:0000791 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IDA
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    transcription repressor complex GO:0017053 IEA
    transcription repressor complex GO:0017053 ISO
 Experiment description of studies that identified H1f0 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for H1f0
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Cdk2  
Biochemical Activity Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Atxn1  
Affinity Capture-MS Mus musculus
5 Foxp3  
Affinity Capture-MS Mus musculus
6 Cdk1 12534
Biochemical Activity Mus musculus
7 TRIM29 23650
Affinity Capture-MS Homo sapiens
8 Fancd2  
Affinity Capture-MS Mus musculus
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