Gene description for Igf1r
Gene name insulin-like growth factor I receptor
Gene symbol Igf1r
Other names/aliases A330103N21Rik
CD221
D930020L01
IGF-1R
hyft
Species Mus musculus
 Database cross references - Igf1r
ExoCarta ExoCarta_16001
Vesiclepedia VP_16001
Entrez Gene 16001
UniProt Q60751  
 Igf1r identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Igf1r
Molecular Function
    G-protein alpha-subunit binding GO:0001965 ISO
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IGI
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 ISO
    protein tyrosine kinase activity GO:0004713 ISS
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IBA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IDA
    insulin-like growth factor receptor activity GO:0005010 IGI
    insulin-like growth factor receptor activity GO:0005010 ISO
    insulin-like growth factor receptor activity GO:0005010 ISS
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    insulin receptor binding GO:0005158 ISO
    structural molecule activity GO:0005198 ISO
    structural molecule activity GO:0005198 ISS
    protein binding GO:0005515 IPI
    insulin-like growth factor binding GO:0005520 IPI
    insulin-like growth factor binding GO:0005520 ISO
    insulin-like growth factor binding GO:0005520 ISS
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    insulin-like growth factor I binding GO:0031994 ISO
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    identical protein binding GO:0042802 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 ISS
    insulin binding GO:0043559 ISO
    insulin receptor substrate binding GO:0043560 IBA
    insulin receptor substrate binding GO:0043560 ISO
    insulin receptor substrate binding GO:0043560 ISS
    protein-containing complex binding GO:0044877 ISO
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    protein transporter activity GO:0140318 ISO
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    MAPK cascade GO:0000165 IMP
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    immune response GO:0006955 ISO
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    axonogenesis GO:0007409 ISO
    brain development GO:0007420 IMP
    positive regulation of cell population proliferation GO:0008284 ISO
    insulin receptor signaling pathway GO:0008286 IEA
    insulin receptor signaling pathway GO:0008286 ISO
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    epidermis development GO:0008544 IMP
    animal organ morphogenesis GO:0009887 IMP
    negative regulation of muscle cell apoptotic process GO:0010656 ISO
    cerebellum development GO:0021549 ISO
    establishment of cell polarity GO:0030010 ISO
    male sex determination GO:0030238 IMP
    adrenal gland development GO:0030325 IGI
    positive regulation of cell migration GO:0030335 ISO
    mammary gland development GO:0030879 IMP
    exocrine pancreas development GO:0031017 IMP
    neuron projection development GO:0031175 ISO
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    positive regulation of cytokinesis GO:0032467 ISO
    cellular response to insulin stimulus GO:0032869 IMP
    positive regulation of osteoblast proliferation GO:0033690 ISO
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    peptidyl-tyrosine autophosphorylation GO:0038083 IDA
    peptidyl-tyrosine autophosphorylation GO:0038083 ISO
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of protein-containing complex disassembly GO:0043243 ISO
    negative regulation of MAPK cascade GO:0043409 IMP
    positive regulation of MAPK cascade GO:0043410 IBA
    positive regulation of MAPK cascade GO:0043410 IMP
    negative regulation of DNA-binding transcription factor activity GO:0043433 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP
    estrous cycle GO:0044849 ISO
    transcytosis GO:0045056 ISO
    response to ethanol GO:0045471 ISO
    positive regulation of mitotic nuclear division GO:0045840 IMP
    positive regulation of DNA-templated transcription GO:0045893 IGI
    regulation of JNK cascade GO:0046328 IBA
    regulation of JNK cascade GO:0046328 ISO
    protein autophosphorylation GO:0046777 ISO
    protein autophosphorylation GO:0046777 ISS
    insulin-like growth factor receptor signaling pathway GO:0048009 IBA
    insulin-like growth factor receptor signaling pathway GO:0048009 IC
    insulin-like growth factor receptor signaling pathway GO:0048009 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IGI
    insulin-like growth factor receptor signaling pathway GO:0048009 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 ISO
    insulin-like growth factor receptor signaling pathway GO:0048009 ISS
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    positive regulation of developmental growth GO:0048639 IMP
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    positive regulation of axon regeneration GO:0048680 ISO
    positive regulation of DNA metabolic process GO:0051054 ISO
    positive regulation of meiotic cell cycle GO:0051446 IGI
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP
    prostate gland epithelium morphogenesis GO:0060740 IMP
    cellular response to glucose stimulus GO:0071333 IBA
    cellular response to glucose stimulus GO:0071333 IMP
    cellular response to transforming growth factor beta stimulus GO:0071560 ISO
    positive regulation of steroid hormone biosynthetic process GO:0090031 ISO
    dendritic spine maintenance GO:0097062 ISO
    amyloid-beta clearance GO:0097242 ISO
    postsynaptic modulation of chemical synaptic transmission GO:0099170 EXP
    postsynaptic modulation of chemical synaptic transmission GO:0099170 IDA
    positive regulation of cold-induced thermogenesis GO:0120162 IMP
    mitotic nuclear division GO:0140014 IMP
    response to L-glutamate GO:1902065 ISO
    negative regulation of hepatocyte apoptotic process GO:1903944 ISO
    negative regulation of cholangiocyte apoptotic process GO:1904193 ISO
    cellular response to amyloid-beta GO:1904646 ISO
    cellular response to insulin-like growth factor stimulus GO:1990314 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    insulin receptor complex GO:0005899 IBA
    caveola GO:0005901 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    T-tubule GO:0030315 IDA
    T-tubule GO:0030315 ISO
    axon GO:0030424 IBA
    axon GO:0030424 ISO
    alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 ISO
    neuronal cell body GO:0043025 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    receptor complex GO:0043235 ISO
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
    protein kinase complex GO:1902911 ISO
 Experiment description of studies that identified Igf1r in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Igf1r
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mdm2  
Affinity Capture-Western Mus musculus
2 Nphs2  
Affinity Capture-MS Mus musculus
3 Irs1  
Biochemical Activity Mus musculus
4 Snx9 66616
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
5 Pcna 18538
Affinity Capture-Western Mus musculus
6 Grb10  
Co-crystal Structure Mus musculus
Affinity Capture-Western Mus musculus
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