Gene description for Lyn
Gene name	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Gene symbol	Lyn
Other names/aliases	AA407514 Hck-2 p53Lyn p56Lyn
Species	Mus musculus
Database cross references - Lyn
ExoCarta	ExoCarta_17096
Vesiclepedia	VP_17096
Entrez Gene	17096
UniProt	P25911
Lyn identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846
Mast cells	17486113

Gene ontology annotations for Lyn

Molecular Function     protein kinase activity GO:0004672 IDA     protein tyrosine kinase activity GO:0004713 EXP     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 ISO     protein tyrosine kinase activity GO:0004713 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IMP     non-membrane spanning protein tyrosine kinase activity GO:0004715 ISO     signaling receptor binding GO:0005102 IBA     signaling receptor binding GO:0005102 ISO     erythropoietin receptor binding GO:0005128 TAS     platelet-derived growth factor receptor binding GO:0005161 IEA     platelet-derived growth factor receptor binding GO:0005161 ISO     integrin binding GO:0005178 IEA     integrin binding GO:0005178 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     SH3 domain binding GO:0017124 IPI     enzyme binding GO:0019899 ISO     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     histone H3Y41 kinase activity GO:0035401 IEA     gamma-tubulin binding GO:0043015 IEA     gamma-tubulin binding GO:0043015 ISO     glycosphingolipid binding GO:0043208 IEA     glycosphingolipid binding GO:0043208 ISO     transmembrane transporter binding GO:0044325 IEA     transmembrane transporter binding GO:0044325 ISO     protein-containing complex binding GO:0044877 IPI     protein-containing complex binding GO:0044877 ISO     ephrin receptor binding GO:0046875 IEA     ephrin receptor binding GO:0046875 ISO     phosphoprotein binding GO:0051219 IEA     phosphoprotein binding GO:0051219 ISO     scaffold protein binding GO:0097110 IEA     scaffold protein binding GO:0097110 ISO     phosphorylation-dependent protein binding GO:0140031 IEA     phosphorylation-dependent protein binding GO:0140031 ISO     histone H2AXY142 kinase activity GO:0140801 IEA     phosphatidylinositol 3-kinase activator activity GO:0141038 IMP Biological Process     DNA damage checkpoint signaling GO:0000077 IEA     DNA damage checkpoint signaling GO:0000077 ISO     cell morphogenesis GO:0000902 IGI     B cell homeostasis GO:0001782 IMP     regulation of cytokine production GO:0001817 IMP     negative regulation of protein phosphorylation GO:0001933 IMP     positive regulation of protein phosphorylation GO:0001934 ISO     hematopoietic progenitor cell differentiation GO:0002244 IEA     hematopoietic progenitor cell differentiation GO:0002244 ISO     adaptive immune response GO:0002250 IEA     Fc receptor mediated stimulatory signaling pathway GO:0002431 IBA     Fc receptor mediated stimulatory signaling pathway GO:0002431 IMP     tolerance induction to self antigen GO:0002513 IBA     tolerance induction to self antigen GO:0002513 IMP     histamine secretion by mast cell GO:0002553 IEA     histamine secretion by mast cell GO:0002553 ISO     platelet degranulation GO:0002576 IMP     negative regulation of myeloid leukocyte differentiation GO:0002762 IMP     immune response-regulating cell surface receptor signaling pathway GO:0002768 IMP     Fc receptor mediated inhibitory signaling pathway GO:0002774 IMP     regulation of B cell apoptotic process GO:0002902 IMP     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 ISO     autophagy GO:0006914 IGI     autophagy GO:0006914 IMP     DNA damage response GO:0006974 IBA     DNA damage response GO:0006974 ISO     response to sterol depletion GO:0006991 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 ISO     positive regulation of cell population proliferation GO:0008284 IMP     negative regulation of cell population proliferation GO:0008285 IMP     negative regulation of cell population proliferation GO:0008285 ISO     response to xenobiotic stimulus GO:0009410 IEA     response to toxic substance GO:0009636 IEA     response to hormone GO:0009725 IDA     response to carbohydrate GO:0009743 IEA     positive regulation of neuron projection development GO:0010976 IEA     positive regulation of neuron projection development GO:0010976 ISO     oligodendrocyte development GO:0014003 IEA     response to organic cyclic compound GO:0014070 IEA     fatty acid transport GO:0015908 IEA     fatty acid transport GO:0015908 ISO     peptidyl-tyrosine phosphorylation GO:0018108 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IMP     peptidyl-tyrosine phosphorylation GO:0018108 ISO     hemopoiesis GO:0030097 IMP     erythrocyte differentiation GO:0030218 IMP     eosinophil differentiation GO:0030222 IEA     eosinophil differentiation GO:0030222 ISO     positive regulation of cell migration GO:0030335 IMP     negative regulation of B cell proliferation GO:0030889 IMP     neuron projection development GO:0031175 IBA     neuron projection development GO:0031175 IMP     lipopolysaccharide-mediated signaling pathway GO:0031663 IMP     response to insulin GO:0032868 IEA     regulation of mast cell activation GO:0033003 IMP     regulation of cell adhesion mediated by integrin GO:0033628 IEA     regulation of cell adhesion mediated by integrin GO:0033628 ISO     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 IMP     toll-like receptor 4 signaling pathway GO:0034142 IMP     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IMP     cellular response to heat GO:0034605 IEA     intracellular signal transduction GO:0035556 IDA     interleukin-5-mediated signaling pathway GO:0038043 IEA     interleukin-5-mediated signaling pathway GO:0038043 ISO     C-X-C chemokine receptor CXCR4 signaling pathway GO:0038159 IEA     C-X-C chemokine receptor CXCR4 signaling pathway GO:0038159 ISO     positive regulation of phosphorylation GO:0042327 IEA     positive regulation of phosphorylation GO:0042327 ISO     hemoglobin biosynthetic process GO:0042541 TAS     response to amino acid GO:0043200 IEA     regulation of mast cell degranulation GO:0043304 IMP     negative regulation of MAP kinase activity GO:0043407 IMP     positive regulation of MAPK cascade GO:0043410 IEA     positive regulation of MAPK cascade GO:0043410 ISO     innate immune response GO:0045087 IEA     regulation of erythrocyte differentiation GO:0045646 IMP     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 ISO     protein autophosphorylation GO:0046777 TAS     response to axon injury GO:0048678 IEA     regulation of inflammatory response GO:0050727 IMP     B cell receptor signaling pathway GO:0050853 IDA     B cell receptor signaling pathway GO:0050853 IGI     regulation of B cell receptor signaling pathway GO:0050855 IBA     regulation of B cell receptor signaling pathway GO:0050855 IMP     regulation of release of sequestered calcium ion into cytosol GO:0051279 IGI     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO     positive regulation of glial cell proliferation GO:0060252 IEA     positive regulation of glial cell proliferation GO:0060252 ISO     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IEA     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 ISO     regulation of ERK1 and ERK2 cascade GO:0070372 IMP     negative regulation of ERK1 and ERK2 cascade GO:0070373 IMP     positive regulation of oligodendrocyte progenitor proliferation GO:0070447 IEA     positive regulation of oligodendrocyte progenitor proliferation GO:0070447 ISO     negative regulation of mast cell proliferation GO:0070667 IMP     positive regulation of mast cell proliferation GO:0070668 IEA     positive regulation of mast cell proliferation GO:0070668 ISO     cellular response to retinoic acid GO:0071300 IEA     cellular response to retinoic acid GO:0071300 ISO     regulation of monocyte chemotaxis GO:0090025 IEA     regulation of monocyte chemotaxis GO:0090025 ISO     regulation of platelet aggregation GO:0090330 IMP     dendritic cell differentiation GO:0097028 IBA     dendritic cell differentiation GO:0097028 IMP     neuroinflammatory response GO:0150076 IGI     negative regulation of intracellular signal transduction GO:1902532 IMP     positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961 ISO     positive regulation of dendritic cell apoptotic process GO:2000670 IMP Subcellular Localization     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IDA     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     adherens junction GO:0005912 IEA     adherens junction GO:0005912 ISO     cytoplasmic side of plasma membrane GO:0009898 IEA     cytoplasmic side of plasma membrane GO:0009898 ISO     mitochondrial crista GO:0030061 IEA     mitochondrial crista GO:0030061 ISO     mitochondrial membrane GO:0031966 ISO     protein-containing complex GO:0032991 IDA     integrin alpha2-beta1 complex GO:0034666 IEA     integrin alpha2-beta1 complex GO:0034666 ISO     intracellular membrane-bounded organelle GO:0043231 ISO     membrane raft GO:0045121 IDA     membrane raft GO:0045121 ISO     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     postsynaptic specialization, intracellular component GO:0099091 IEA     postsynaptic specialization, intracellular component GO:0099091 ISO