Gene description for Sox11
Gene name SRY (sex determining region Y)-box 11
Gene symbol Sox11
Other names/aliases 1110038H03Rik
6230403H02Rik
AI836553
end1
Species Mus musculus
 Database cross references - Sox11
ExoCarta ExoCarta_20666
Vesiclepedia VP_20666
Entrez Gene 20666
UniProt Q7M6Y2  
 Sox11 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sox11
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    DNA-binding transcription factor activity GO:0003700 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    kidney development GO:0001822 IEA
    lens morphogenesis in camera-type eye GO:0002089 IMP
    outflow tract morphogenesis GO:0003151 IMP
    noradrenergic neuron differentiation GO:0003357 IMP
    noradrenergic neuron differentiation GO:0003357 ISO
    nervous system development GO:0007399 IMP
    brain development GO:0007420 IBA
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IMP
    negative regulation of gene expression GO:0010629 ISO
    oligodendrocyte development GO:0014003 IEA
    glial cell proliferation GO:0014009 IMP
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IEA
    spinal cord development GO:0021510 IMP
    glial cell development GO:0021782 IMP
    neuron differentiation GO:0030182 IBA
    positive regulation of BMP signaling pathway GO:0030513 IMP
    positive regulation of hippo signaling GO:0035332 IMP
    skeletal muscle cell differentiation GO:0035914 IMP
    positive regulation of neuron differentiation GO:0045666 IDA
    positive regulation of neuron differentiation GO:0045666 IMP
    positive regulation of neuron differentiation GO:0045666 ISO
    positive regulation of osteoblast differentiation GO:0045669 ISO
    positive regulation of osteoblast differentiation GO:0045669 ISS
    positive regulation of ossification GO:0045778 IMP
    positive regulation of ossification GO:0045778 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of hormone secretion GO:0046887 IMP
    sympathetic nervous system development GO:0048485 IMP
    embryonic digestive tract morphogenesis GO:0048557 IMP
    camera-type eye morphogenesis GO:0048593 IBA
    embryonic skeletal system morphogenesis GO:0048704 IMP
    negative regulation of lymphocyte proliferation GO:0050672 IEA
    negative regulation of lymphocyte proliferation GO:0050672 ISO
    positive regulation of neurogenesis GO:0050769 IDA
    hard palate development GO:0060022 IMP
    soft palate development GO:0060023 IMP
    negative regulation of glial cell proliferation GO:0060253 IMP
    negative regulation of glial cell proliferation GO:0060253 ISO
    ventricular septum morphogenesis GO:0060412 IMP
    lung morphogenesis GO:0060425 IMP
    neuroepithelial cell differentiation GO:0060563 IMP
    eyelid development in camera-type eye GO:0061029 IMP
    cornea development in camera-type eye GO:0061303 IMP
    closure of optic fissure GO:0061386 IMP
    positive regulation of stem cell proliferation GO:2000648 ISO
    positive regulation of stem cell proliferation GO:2000648 ISS
    negative regulation of transcription regulatory region DNA binding GO:2000678 ISS
    positive regulation of lens epithelial cell proliferation GO:2001111 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Sox11 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sox11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hist1h3f 260423
Co-localization Mus musculus
View the network image/svg+xml
 Pathways in which Sox11 is involved
No pathways found





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