Gene description for DAAM2
Gene name dishevelled associated activator of morphogenesis 2
Gene symbol DAAM2
Other names/aliases dJ90A20A.1
Species Homo sapiens
 Database cross references - DAAM2
ExoCarta ExoCarta_23500
Vesiclepedia VP_23500
Entrez Gene 23500
HGNC 18143
MIM 606627
UniProt Q86T65  
 DAAM2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DAAM2
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
Biological Process
    determination of left/right symmetry GO:0007368 IEA
    Wnt signaling pathway GO:0016055 IEA
    dorsal spinal cord development GO:0021516 ISS
    actin cytoskeleton organization GO:0030036 IEA
    positive regulation of cell migration GO:0030335 IMP
    regulation of actin filament polymerization GO:0030833 IDA
    regulation of actin cytoskeleton organization GO:0032956 IMP
    negative regulation of oligodendrocyte differentiation GO:0048715 IBA
    negative regulation of oligodendrocyte differentiation GO:0048715 ISS
    regulation of filopodium assembly GO:0051489 IDA
    regulation of canonical Wnt signaling pathway GO:0060828 ISS
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISS
    podocyte cell migration GO:0090521 IDA
    regulation of non-canonical Wnt signaling pathway GO:2000050 IBA
    regulation of non-canonical Wnt signaling pathway GO:2000050 ISS
Subcellular Localization
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified DAAM2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DAAM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 CD320 51293
Affinity Capture-MS Homo sapiens
3 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RBMY1F  
Two-hybrid Homo sapiens
5 RBMY1A1  
Two-hybrid Homo sapiens
6 TH  
Two-hybrid Homo sapiens
7 RHOC 389
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 REL 5966
Two-hybrid Homo sapiens
9 EHHADH 1962
Two-hybrid Homo sapiens
10 CUL5 8065
Affinity Capture-MS Homo sapiens
11 KCNIP1  
Two-hybrid Homo sapiens
12 ACVR2A  
Affinity Capture-MS Homo sapiens
13 MDFI  
Two-hybrid Homo sapiens
14 KRTAP10-3  
Two-hybrid Homo sapiens
15 KRTAP10-1  
Two-hybrid Homo sapiens
16 MCAM 4162
Proximity Label-MS Homo sapiens
17 PRAME  
Affinity Capture-MS Homo sapiens
18 UBB 7314
Affinity Capture-MS Homo sapiens
19 KRTAP10-8  
Two-hybrid Homo sapiens
20 KRT40  
Two-hybrid Homo sapiens
21 HGS 9146
Two-hybrid Homo sapiens
22 LGR4 55366
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NFATC2IP  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DAAM2 is involved
No pathways found





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