Gene description for GYPC
Gene name glycophorin C (Gerbich blood group)
Gene symbol GYPC
Other names/aliases CD236
CD236R
GE
GPC
GPD
GYPD
PAS-2
PAS-2'
Species Homo sapiens
 Database cross references - GYPC
ExoCarta ExoCarta_2995
Vesiclepedia VP_2995
Entrez Gene 2995
HGNC 4704
MIM 110750
UniProt P04921  
 GYPC identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for GYPC
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    cortical cytoskeleton GO:0030863 IBA
    cortical cytoskeleton GO:0030863 IDA
 Experiment description of studies that identified GYPC in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GYPC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCAM 4162
Proximity Label-MS Homo sapiens
2 ABHD16A 7920
Two-hybrid Homo sapiens
3 RHBDD1 84236
Two-hybrid Homo sapiens
4 TMEM14B  
Two-hybrid Homo sapiens
5 GPR42  
Two-hybrid Homo sapiens
6 LPPR2  
Two-hybrid Homo sapiens
7 TMEM88  
Two-hybrid Homo sapiens
8 SLC10A6  
Two-hybrid Homo sapiens
9 PDIA3 2923
Reconstituted Complex Homo sapiens
10 KIAA1644  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GYPC is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Hemostasis TAS Reactome





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