Gene description for MACC1
Gene name metastasis associated in colon cancer 1
Gene symbol MACC1
Other names/aliases 7A5
SH3BP4L
Species Homo sapiens
 Database cross references - MACC1
ExoCarta ExoCarta_346389
Vesiclepedia VP_346389
Entrez Gene 346389
HGNC 30215
MIM 612646
UniProt Q6ZN28  
 MACC1 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for MACC1
Molecular Function
    growth factor activity GO:0008083 IEA
Biological Process
    signal transduction GO:0007165 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of cell division GO:0051781 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified MACC1 in sEVs
1
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for MACC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAE 7531
Affinity Capture-MS Homo sapiens
2 MARK3 4140
Affinity Capture-MS Homo sapiens
3 MIB2 142678
Affinity Capture-MS Homo sapiens
4 FASLG 356
Protein-peptide Homo sapiens
5 EPS15 2060
Affinity Capture-MS Homo sapiens
6 MARK2 2011
Affinity Capture-MS Homo sapiens
7 CDH1 999
Proximity Label-MS Homo sapiens
8 FCHO2 115548
Affinity Capture-MS Homo sapiens
9 SRRM1 10250
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which MACC1 is involved
No pathways found





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