Gene description for P2RY2
Gene name purinergic receptor P2Y, G-protein coupled, 2
Gene symbol P2RY2
Other names/aliases HP2U
P2RU1
P2U
P2U1
P2UR
P2Y2
P2Y2R
Species Homo sapiens
 Database cross references - P2RY2
ExoCarta ExoCarta_5029
Vesiclepedia VP_5029
Entrez Gene 5029
HGNC 8541
MIM 600041
UniProt P41231  
 P2RY2 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for P2RY2
Molecular Function
    protein binding GO:0005515 IPI
    A1 adenosine receptor binding GO:0031686 IBA
    signaling receptor activity GO:0038023 TAS
    G protein-coupled purinergic nucleotide receptor activity GO:0045028 IEA
    G protein-coupled UTP receptor activity GO:0045030 IBA
Biological Process
    intracellular monoatomic ion homeostasis GO:0006873 TAS
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA
    G protein-coupled purinergic nucleotide receptor signaling pathway GO:0035589 IEA
    positive regulation of mucus secretion GO:0070257 IEA
    cellular response to ATP GO:0071318 TAS
    blood vessel diameter maintenance GO:0097746 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified P2RY2 in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for P2RY2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC29A1 2030
Affinity Capture-MS Homo sapiens
2 CMTM6 54918
Affinity Capture-MS Homo sapiens
3 ATPIF1 93974
Affinity Capture-MS Homo sapiens
4 DNAJC11 55735
Affinity Capture-MS Homo sapiens
5 DERL2 51009
Affinity Capture-MS Homo sapiens
6 TMEM161A  
Affinity Capture-MS Homo sapiens
7 DHCR24 1718
Affinity Capture-MS Homo sapiens
8 SACM1L 22908
Affinity Capture-MS Homo sapiens
9 TTYH3 80727
Affinity Capture-MS Homo sapiens
10 SLC39A4 55630
Affinity Capture-MS Homo sapiens
11 KIAA2013 90231
Affinity Capture-MS Homo sapiens
12 ATP12A 479
Affinity Capture-MS Homo sapiens
13 SURF4 6836
Affinity Capture-MS Homo sapiens
14 LMBR1  
Affinity Capture-MS Homo sapiens
15 INTS1 26173
Affinity Capture-MS Homo sapiens
16 SYVN1 84447
Affinity Capture-MS Homo sapiens
17 C1orf112  
Affinity Capture-MS Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 KDELR1 10945
Affinity Capture-MS Homo sapiens
20 TOMM22 56993
Affinity Capture-MS Homo sapiens
21 APEX1 328
Affinity Capture-RNA Homo sapiens
22 PTDSS2 81490
Affinity Capture-MS Homo sapiens
23 MAOB  
Affinity Capture-MS Homo sapiens
24 MCU 90550
Affinity Capture-MS Homo sapiens
25 RNF5  
Affinity Capture-MS Homo sapiens
26 SLC39A10 57181
Affinity Capture-MS Homo sapiens
27 RINT1 60561
Affinity Capture-MS Homo sapiens
28 FAM8A1 51439
Affinity Capture-MS Homo sapiens
29 TM9SF4 9777
Affinity Capture-MS Homo sapiens
30 SRC 6714
Affinity Capture-Western Homo sapiens
31 INTS12  
Affinity Capture-MS Homo sapiens
32 RER1 11079
Affinity Capture-MS Homo sapiens
33 ATP2A3 489
Affinity Capture-MS Homo sapiens
34 IPO8 10526
Affinity Capture-MS Homo sapiens
35 MRS2  
Affinity Capture-MS Homo sapiens
36 DNAJC16  
Affinity Capture-MS Homo sapiens
37 SLC30A5 64924
Affinity Capture-MS Homo sapiens
38 ERMP1 79956
Affinity Capture-MS Homo sapiens
39 PIGG  
Affinity Capture-MS Homo sapiens
40 ATP13A3 79572
Affinity Capture-MS Homo sapiens
41 TMEM87A 25963
Affinity Capture-MS Homo sapiens
42 ATP1A3 478
Affinity Capture-MS Homo sapiens
43 HEATR1 55127
Affinity Capture-MS Homo sapiens
44 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
45 NOMO1 23420
Affinity Capture-MS Homo sapiens
46 HS2ST1 9653
Affinity Capture-MS Homo sapiens
47 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
48 ATP9A 10079
Affinity Capture-MS Homo sapiens
49 SCAMP2 10066
Affinity Capture-MS Homo sapiens
50 TMEM259 91304
Affinity Capture-MS Homo sapiens
51 SLC7A6 9057
Affinity Capture-MS Homo sapiens
52 STX5 6811
Affinity Capture-MS Homo sapiens
53 ATP2B4 493
Affinity Capture-MS Homo sapiens
54 SLC4A2 6522
Affinity Capture-MS Homo sapiens
55 CLN3 1201
Affinity Capture-MS Homo sapiens
56 GPAA1 8733
Affinity Capture-MS Homo sapiens
57 FANCD2  
Affinity Capture-MS Homo sapiens
58 ENDOD1 23052
Affinity Capture-MS Homo sapiens
59 YIPF6 286451
Affinity Capture-MS Homo sapiens
60 SLC39A6 25800
Affinity Capture-MS Homo sapiens
61 ATP2B1 490
Affinity Capture-MS Homo sapiens
62 CAV2 858
Affinity Capture-MS Homo sapiens
63 APOB 338
Affinity Capture-MS Homo sapiens
64 SLC30A6 55676
Affinity Capture-MS Homo sapiens
65 ERGIC3 51614
Affinity Capture-MS Homo sapiens
66 DAD1 1603
Affinity Capture-MS Homo sapiens
67 TMEM160 54958
Affinity Capture-MS Homo sapiens
68 RMND1 55005
Affinity Capture-MS Homo sapiens
69 TNPO3 23534
Affinity Capture-MS Homo sapiens
70 TMEM246 84302
Affinity Capture-MS Homo sapiens
71 YIPF5 81555
Affinity Capture-MS Homo sapiens
72 GHITM 27069
Affinity Capture-MS Homo sapiens
73 SGPP1 81537
Affinity Capture-MS Homo sapiens
74 TM9SF3 56889
Affinity Capture-MS Homo sapiens
75 SAAL1 113174
Affinity Capture-MS Homo sapiens
76 XPO4 64328
Affinity Capture-MS Homo sapiens
77 RFT1 91869
Affinity Capture-MS Homo sapiens
78 NLRP3  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
79 TMCO1 54499
Affinity Capture-MS Homo sapiens
80 ITPRIPL1  
Affinity Capture-MS Homo sapiens
81 SLC30A7 148867
Affinity Capture-MS Homo sapiens
82 METTL9 51108
Affinity Capture-MS Homo sapiens
83 DYM  
Affinity Capture-MS Homo sapiens
84 RNF185  
Affinity Capture-MS Homo sapiens
85 THADA 63892
Affinity Capture-MS Homo sapiens
86 MARCH6  
Affinity Capture-MS Homo sapiens
87 UBE2J1 51465
Affinity Capture-MS Homo sapiens
88 ATP2B3 492
Affinity Capture-MS Homo sapiens
89 TPCN1 53373
Affinity Capture-MS Homo sapiens
90 MBOAT7 79143
Affinity Capture-MS Homo sapiens
91 LBR 3930
Affinity Capture-MS Homo sapiens
92 HMGCR  
Affinity Capture-MS Homo sapiens
93 SLC19A2 10560
Affinity Capture-MS Homo sapiens
94 NUP205 23165
Affinity Capture-MS Homo sapiens
95 GOSR1 9527
Affinity Capture-MS Homo sapiens
96 CLPTM1 1209
Affinity Capture-MS Homo sapiens
97 PIGU 128869
Affinity Capture-MS Homo sapiens
98 SLC39A14 23516
Affinity Capture-MS Homo sapiens
99 RABL3 285282
Affinity Capture-MS Homo sapiens
100 MOV10 4343
Affinity Capture-RNA Homo sapiens
101 GOLGA5 9950
Affinity Capture-MS Homo sapiens
102 ADGRE5 976
Affinity Capture-MS Homo sapiens
103 SCAMP3 10067
Affinity Capture-MS Homo sapiens
104 BRI3BP 140707
Affinity Capture-MS Homo sapiens
105 DERL1 79139
Affinity Capture-MS Homo sapiens
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