Gene description for TDP2
Gene name	tyrosyl-DNA phosphodiesterase 2
Gene symbol	TDP2
Other names/aliases	AD022 EAP2 EAPII TTRAP dJ30M3.3 hTDP2
Species	Homo sapiens
Database cross references - TDP2
ExoCarta	ExoCarta_51567
Vesiclepedia	VP_51567
Entrez Gene	51567
HGNC	17768
MIM	605764
UniProt	O95551
TDP2 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells	20124223

Gene ontology annotations for TDP2

Molecular Function     magnesium ion binding GO:0000287 IDA     magnesium ion binding GO:0000287 TAS     single-stranded DNA binding GO:0003697 IBA     single-stranded DNA binding GO:0003697 IDA     transcription corepressor activity GO:0003714 TAS     nuclease activity GO:0004518 IEA     protein binding GO:0005515 IPI     manganese ion binding GO:0030145 IDA     tyrosyl-RNA phosphodiesterase activity GO:0036317 IDA     5'-tyrosyl-DNA phosphodiesterase activity GO:0070260 IBA     5'-tyrosyl-DNA phosphodiesterase activity GO:0070260 IDA     5'-tyrosyl-DNA phosphodiesterase activity GO:0070260 IMP Biological Process     double-strand break repair GO:0006302 IBA     double-strand break repair GO:0006302 IDA     double-strand break repair GO:0006302 IMP     cell surface receptor signaling pathway GO:0007166 TAS     negative regulation of DNA-templated transcription GO:0045892 IEA     neuron development GO:0048666 IMP Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleolus GO:0005730 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     aggresome GO:0016235 IDA     nuclear body GO:0016604 IDA     PML body GO:0016605 IBA     PML body GO:0016605 IDA