Gene description for SORCS2
Gene name sortilin-related VPS10 domain containing receptor 2
Gene symbol SORCS2
Other names/aliases -
Species Homo sapiens
 Database cross references - SORCS2
ExoCarta ExoCarta_57537
Vesiclepedia VP_57537
Entrez Gene 57537
HGNC 16698
MIM 606284
UniProt Q96PQ0  
 SORCS2 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SORCS2
Molecular Function
    neuropeptide receptor activity GO:0008188 NAS
Biological Process
    intracellular protein transport GO:0006886 IEA
    neuropeptide signaling pathway GO:0007218 NAS
    long-term synaptic depression GO:0060292 IEA
Subcellular Localization
    cytosol GO:0005829 IDA
    membrane GO:0016020 IBA
    membrane GO:0016020 NAS
    early endosome membrane GO:0031901 IEA
    dendritic spine GO:0043197 IEA
    perikaryon GO:0043204 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    recycling endosome membrane GO:0055038 IEA
    postsynaptic density membrane GO:0098839 IEA
 Experiment description of studies that identified SORCS2 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SORCS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCAF10  
Affinity Capture-MS Homo sapiens
2 FNDC3A 22862
Affinity Capture-MS Homo sapiens
3 HMGCR  
Affinity Capture-MS Homo sapiens
4 NXT2  
Affinity Capture-MS Homo sapiens
5 TTC1 7265
Affinity Capture-MS Homo sapiens
6 KIF14 9928
Affinity Capture-MS Homo sapiens
7 CSTF2T  
Affinity Capture-MS Homo sapiens
8 MYH4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SORCS2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here