Gene description for Rnf130
Gene name ring finger protein 130
Gene symbol Rnf130
Other names/aliases 2510042A13Rik
G1RZFP
G1rp
GOLIATH
GP
Species Mus musculus
 Database cross references - Rnf130
ExoCarta ExoCarta_59044
Vesiclepedia VP_59044
Entrez Gene 59044
UniProt Q8VEM1  
 Rnf130 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rnf130
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISO
    ubiquitin-protein transferase activity GO:0004842 ISS
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    apoptotic process GO:0006915 IEA
    programmed cell death GO:0012501 IMP
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    membrane GO:0016020 NAS
 Experiment description of studies that identified Rnf130 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rnf130
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Srebf1  
Affinity Capture-MS Rattus norvegicus
2 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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