Gene description for RNASE2
Gene name ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
Gene symbol RNASE2
Other names/aliases EDN
RAF3
RNS2
Species Homo sapiens
 Database cross references - RNASE2
ExoCarta ExoCarta_6036
Vesiclepedia VP_6036
Entrez Gene 6036
HGNC 10045
MIM 131410
UniProt P10153  
 RNASE2 identified in sEVs derived from the following tissue/cell type
Urine 15326289    
 Gene ontology annotations for RNASE2
Molecular Function
    lipopolysaccharide binding GO:0001530 IMP
    nucleic acid binding GO:0003676 IEA
    ribonuclease A activity GO:0004522 IEA
    RNA nuclease activity GO:0004540 IBA
    RNA nuclease activity GO:0004540 IDA
    protein binding GO:0005515 IPI
    lyase activity GO:0016829 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IBA
    RNA catabolic process GO:0006401 TAS
    chemotaxis GO:0006935 IBA
    chemotaxis GO:0006935 IDA
    induction of bacterial agglutination GO:0043152 IMP
    defense response to Gram-negative bacterium GO:0050829 IMP
    defense response to Gram-positive bacterium GO:0050830 IMP
    defense response to virus GO:0051607 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    azurophil granule lumen GO:0035578 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified RNASE2 in sEVs
1
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for RNASE2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCP2  
Affinity Capture-MS Homo sapiens
2 DLG2 1740
Two-hybrid Homo sapiens
3 YWHAQ 10971
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RNASE2 is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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