Gene description for CLSTN2
Gene name calsyntenin 2
Gene symbol CLSTN2
Other names/aliases ALC-GAMMA
CDHR13
CS2
CSTN2
alcagamma
Species Homo sapiens
 Database cross references - CLSTN2
ExoCarta ExoCarta_64084
Vesiclepedia VP_64084
Entrez Gene 64084
HGNC 17448
MIM 611323
UniProt Q9H4D0  
 CLSTN2 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CLSTN2
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    associative learning GO:0008306 IEA
    positive regulation of synaptic transmission GO:0050806 IBA
    positive regulation of synapse assembly GO:0051965 IBA
    inhibitory synapse assembly GO:1904862 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    cell surface GO:0009986 IBA
    dendrite GO:0030425 IEA
    postsynaptic membrane GO:0045211 IBA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified CLSTN2 in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CLSTN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTP20 27340
Affinity Capture-MS Homo sapiens
2 NUP160 23279
Affinity Capture-MS Homo sapiens
3 ZMYM1 79830
Affinity Capture-MS Homo sapiens
4 NUP85 79902
Affinity Capture-MS Homo sapiens
5 SGPL1 8879
Affinity Capture-MS Homo sapiens
6 CUX1 1523
Affinity Capture-MS Homo sapiens
7 BPIFA1 51297
Affinity Capture-MS Homo sapiens
8 SPTB 6710
Affinity Capture-MS Homo sapiens
9 NUP37 79023
Affinity Capture-MS Homo sapiens
10 APBA3  
Affinity Capture-MS Homo sapiens
11 SLC12A7 10723
Affinity Capture-MS Homo sapiens
12 SMARCA2 6595
Affinity Capture-MS Homo sapiens
13 TYK2 7297
Affinity Capture-MS Homo sapiens
14 NUP43 348995
Affinity Capture-MS Homo sapiens
15 UFSP2 55325
Affinity Capture-MS Homo sapiens
16 RPL23 9349
Affinity Capture-MS Homo sapiens
17 EXOC3 11336
Affinity Capture-MS Homo sapiens
18 CLSTN1 22883
Affinity Capture-MS Homo sapiens
19 LMAN1 3998
Affinity Capture-MS Homo sapiens
20 MYCBP2 23077
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CLSTN2 is involved
No pathways found





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