Gene description for PCNXL4
Gene name pecanex-like 4 (Drosophila)
Gene symbol PCNXL4
Other names/aliases C14orf135
FBP2
Species Homo sapiens
 Database cross references - PCNXL4
ExoCarta ExoCarta_64430
Vesiclepedia VP_64430
Entrez Gene 64430
HGNC 20349
UniProt Q63HM2  
 PCNXL4 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PCNXL4
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified PCNXL4 in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PCNXL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRD2  
Affinity Capture-MS Homo sapiens
2 FBP1 2203
Two-hybrid Homo sapiens
3 CEP63  
Two-hybrid Homo sapiens
4 MTNR1B  
Two-hybrid Homo sapiens
5 DISC1 27185
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PCNXL4 is involved
No pathways found





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