Gene description for SNCG
Gene name synuclein, gamma (breast cancer-specific protein 1)
Gene symbol SNCG
Other names/aliases BCSG1
SR
Species Homo sapiens
 Database cross references - SNCG
ExoCarta ExoCarta_6623
Vesiclepedia VP_6623
Entrez Gene 6623
HGNC 11141
MIM 602998
UniProt O76070  
 SNCG identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for SNCG
Molecular Function
    protein binding GO:0005515 IPI
    cuprous ion binding GO:1903136 IBA
Biological Process
    chemical synaptic transmission GO:0007268 IBA
    adult locomotory behavior GO:0008344 IEA
    protein secretion GO:0009306 IEA
    regulation of dopamine secretion GO:0014059 IEA
    regulation of neurotransmitter secretion GO:0046928 IEA
    synaptic vesicle endocytosis GO:0048488 IBA
    synapse organization GO:0050808 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    spindle GO:0005819 IEA
    neuronal cell body GO:0043025 IBA
    axon terminus GO:0043679 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SNCG in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
6
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SNCG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRK5 2869
Biochemical Activity Homo sapiens
2 MAPK3 5595
Affinity Capture-Western Homo sapiens
3 GRK6 2870
Biochemical Activity Homo sapiens
4 ILF3 3609
Co-fractionation Homo sapiens
5 POT1  
Two-hybrid Homo sapiens
6 AHCYL1 10768
Co-fractionation Homo sapiens
7 FABP4 2167
Affinity Capture-MS Homo sapiens
8 MAPK1 5594
Affinity Capture-Western Homo sapiens
9 SULT1A1 6817
Co-fractionation Homo sapiens
10 HN1 51155
Co-fractionation Homo sapiens
11 MCM3 4172
Affinity Capture-MS Homo sapiens
12 ADRB2  
PCA Homo sapiens
13 Bmpr1a  
Affinity Capture-MS Mus musculus
14 SSSCA1 10534
Co-fractionation Homo sapiens
15 POU4F3  
Affinity Capture-MS Homo sapiens
16 BUB1B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
17 CEP41  
Co-fractionation Homo sapiens
18 TERF2IP 54386
Two-hybrid Homo sapiens
19 SIRT5 23408
Affinity Capture-MS Homo sapiens
20 WIF1 11197
Affinity Capture-MS Homo sapiens
21 TUFM 7284
Co-fractionation Homo sapiens
22 HNF4A  
Affinity Capture-MS Homo sapiens
23 TERF1 7013
Two-hybrid Homo sapiens
24 UBA2 10054
Co-fractionation Homo sapiens
25 EXT2 2132
Affinity Capture-MS Homo sapiens
26 FUBP1 8880
Affinity Capture-MS Homo sapiens
27 GRK1  
Biochemical Activity Homo sapiens
28 ADRBK1 282682
Biochemical Activity Bos taurus
29 CIDEB  
Affinity Capture-MS Homo sapiens
30 MAPK8 5599
Affinity Capture-Western Homo sapiens
31 Cenpe  
Affinity Capture-MS Mus musculus
32 TIMP2 7077
Affinity Capture-MS Homo sapiens
33 GPR173  
Affinity Capture-MS Homo sapiens
34 SEMA4B  
Co-fractionation Homo sapiens
35 DYNLL1 8655
Affinity Capture-MS Homo sapiens
36 SLC6A4 6532
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which SNCG is involved
No pathways found





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