Gene description for MYRF
Gene name myelin regulatory factor
Gene symbol MYRF
Other names/aliases C11orf9
MRF
Ndt80
pqn-47
Species Homo sapiens
 Database cross references - MYRF
ExoCarta ExoCarta_745
Vesiclepedia VP_745
Entrez Gene 745
HGNC 1181
MIM 608329
UniProt Q9Y2G1  
 MYRF identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MYRF
Molecular Function
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IEA
    DNA binding GO:0003677 ISS
    DNA-binding transcription factor activity GO:0003700 IBA
    DNA-binding transcription factor activity GO:0003700 ISS
    peptidase activity GO:0008233 IEA
    identical protein binding GO:0042802 IPI
    sequence-specific DNA binding GO:0043565 IBA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    oligodendrocyte development GO:0014003 ISS
    protein autoprocessing GO:0016540 IBA
    protein autoprocessing GO:0016540 ISS
    central nervous system myelination GO:0022010 ISS
    positive regulation of myelination GO:0031643 ISS
    central nervous system myelin maintenance GO:0032286 IBA
    central nervous system myelin maintenance GO:0032286 ISS
    positive regulation of DNA-templated transcription GO:0045893 IBA
    positive regulation of DNA-templated transcription GO:0045893 ISS
    oligodendrocyte differentiation GO:0048709 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 ISS
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified MYRF in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MYRF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNE3  
Affinity Capture-MS Homo sapiens
2 GPRC5B 51704
Affinity Capture-MS Homo sapiens
3 PCDHB3  
Affinity Capture-MS Homo sapiens
4 GRAMD3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYRF is involved
No pathways found





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