Gene description for Anxa6
Gene name annexin A6
Gene symbol Anxa6
Other names/aliases Anx6
CPB-II
Species Rattus norvegicus
 Database cross references - Anxa6
ExoCarta ExoCarta_79125
Vesiclepedia VP_79125
Entrez Gene 79125
 Anxa6 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Cortical neurones 16446100    
Hepatocytes 19367702    
 Gene ontology annotations for Anxa6
Molecular Function
    phosphatidylserine binding GO:0001786 IBA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 ISO
    calcium-dependent phospholipid binding GO:0005544 IBA
    calcium-dependent phospholipid binding GO:0005544 IDA
    calcium-dependent phospholipid binding GO:0005544 IEA
    calcium-dependent phospholipid binding GO:0005544 ISO
    calcium-dependent phospholipid binding GO:0005544 TAS
    lipid binding GO:0008289 ISO
    ligand-gated monoatomic ion channel activity GO:0015276 ISO
    cholesterol binding GO:0015485 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 IPI
    calcium-dependent protein binding GO:0048306 ISO
Biological Process
    calcium ion transport GO:0006816 IBA
    calcium ion transport GO:0006816 IEA
    calcium ion transport GO:0006816 ISO
    regulation of muscle contraction GO:0006937 IEA
    regulation of muscle contraction GO:0006937 ISO
    monoatomic ion transmembrane transport GO:0034220 ISO
    secretion GO:0046903 TAS
    negative regulation of sequestering of calcium ion GO:0051283 IBA
    mitochondrial calcium ion homeostasis GO:0051560 IBA
    mitochondrial calcium ion homeostasis GO:0051560 IEA
    mitochondrial calcium ion homeostasis GO:0051560 ISO
    apoptotic signaling pathway GO:0097190 IBA
    apoptotic signaling pathway GO:0097190 IEA
    apoptotic signaling pathway GO:0097190 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IEA
    lysosomal membrane GO:0005765 ISO
    plasma membrane GO:0005886 IBA
    vesicle membrane GO:0012506 IBA
    intercalated disc GO:0014704 IDA
    membrane GO:0016020 IDA
    apical plasma membrane GO:0016324 IDA
    late endosome membrane GO:0031902 ISO
    protein-containing complex GO:0032991 IDA
    sarcolemma GO:0042383 IDA
    melanosome GO:0042470 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Anxa6 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 30
MISEV standards
EM
Biophysical techniques
Alix|TSG101|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16446100    
Organism Rattus norvegicus
Experiment description Exosomes are released by cultured cortical neurones.
Authors "Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R"
Journal name MCN
Publication year 2006
Sample Cortical neurones
Sample name Cortical neurones
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
4
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Anxa6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Anxa6 is involved
No pathways found





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