Gene description for ADIPOR2
Gene name adiponectin receptor 2
Gene symbol ADIPOR2
Other names/aliases ACDCR2
PAQR2
Species Homo sapiens
 Database cross references - ADIPOR2
ExoCarta ExoCarta_79602
Vesiclepedia VP_79602
Entrez Gene 79602
HGNC 24041
MIM 607946
UniProt Q86V24  
 ADIPOR2 identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ADIPOR2
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IBA
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
    adiponectin binding GO:0055100 IDA
    adipokinetic hormone receptor activity GO:0097003 IDA
Biological Process
    hormone-mediated signaling pathway GO:0009755 ISS
    fatty acid oxidation GO:0019395 ISS
    adiponectin-activated signaling pathway GO:0033211 IBA
    adiponectin-activated signaling pathway GO:0033211 IDA
    glucose homeostasis GO:0042593 ISS
    vascular wound healing GO:0061042 ISS
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified ADIPOR2 in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ADIPOR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 NCK2 8440
Affinity Capture-MS Homo sapiens
3 NEU2  
Affinity Capture-MS Homo sapiens
4 DUSP6 1848
Affinity Capture-MS Homo sapiens
5 NCK1 4690
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 APPL1 26060
Affinity Capture-Western Homo sapiens
7 RNF181  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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