Gene description for Senp3
Gene name SUMO/sentrin specific peptidase 3
Gene symbol Senp3
Other names/aliases AA408656
Smt3ip
Smt3ip1
Species Mus musculus
 Database cross references - Senp3
ExoCarta ExoCarta_80886
Vesiclepedia VP_80886
Entrez Gene 80886
UniProt Q9EP97  
 Senp3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Senp3
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IDA
    protein binding GO:0005515 IPI
    cysteine-type peptidase activity GO:0008234 ISO
    deSUMOylase activity GO:0016929 IBA
    deSUMOylase activity GO:0016929 ISO
    deSUMOylase activity GO:0016929 ISS
Biological Process
    proteolysis GO:0006508 IEA
    protein desumoylation GO:0016926 IBA
    protein desumoylation GO:0016926 ISO
    protein desumoylation GO:0016926 ISS
    protein metabolic process GO:0019538 IDA
    negative regulation of double-strand break repair via homologous recombination GO:2000042 IEA
    negative regulation of double-strand break repair via homologous recombination GO:2000042 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IEA
    MLL1 complex GO:0071339 ISO
    MLL1 complex GO:0071339 ISS
 Experiment description of studies that identified Senp3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Senp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nanog  
Affinity Capture-MS Mus musculus
2 Mycbp2 105689
Affinity Capture-MS Mus musculus
3 Foxp3  
Affinity Capture-MS Mus musculus
4 Elf5  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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