Gene description for RILP
Gene name Rab interacting lysosomal protein
Gene symbol RILP
Other names/aliases PP10141
Species Homo sapiens
 Database cross references - RILP
ExoCarta ExoCarta_83547
Vesiclepedia VP_83547
Entrez Gene 83547
HGNC 30266
MIM 607848
UniProt Q96NA2  
 RILP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RILP
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
    small GTPase binding GO:0031267 IPI
    small GTPase binding GO:0031267 TAS
    protein dimerization activity GO:0046983 IEA
    dynein light intermediate chain binding GO:0051959 IBA
    dynein light intermediate chain binding GO:0051959 IPI
Biological Process
    endosome to lysosome transport GO:0008333 IMP
    protein transport GO:0015031 NAS
    endosome transport via multivesicular body sorting pathway GO:0032509 IDA
    negative regulation of protein catabolic process GO:0042177 IDA
    early endosome to late endosome transport GO:0045022 IBA
    early endosome to late endosome transport GO:0045022 IMP
    positive regulation of protein catabolic process GO:0045732 IMP
    cilium assembly GO:0060271 IBA
    intralumenal vesicle formation GO:0070676 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 NAS
    lysosomal membrane GO:0005765 TAS
    late endosome GO:0005770 IDA
    late endosome GO:0005770 NAS
    phagocytic vesicle membrane GO:0030670 IEA
    late endosome membrane GO:0031902 IEA
    protein-containing complex GO:0032991 IEA
    ciliary basal body GO:0036064 IBA
 Experiment description of studies that identified RILP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RILP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB7B  
Affinity Capture-Western Homo sapiens
2 VPS36 51028
Reconstituted Complex Homo sapiens
3 EIF2S1 1965
Affinity Capture-MS Homo sapiens
4 VPS16 64601
Reconstituted Complex Homo sapiens
5 VPS41 27072
Reconstituted Complex Homo sapiens
6 KIF1A 547
Affinity Capture-MS Homo sapiens
7 DDX58 23586
Affinity Capture-RNA Homo sapiens
8 RAB34 83871
Affinity Capture-MS Homo sapiens
9 LDB2  
Two-hybrid Homo sapiens
10 MEX3A  
Affinity Capture-RNA Homo sapiens
11 ORC3  
Affinity Capture-MS Homo sapiens
12 KPNA2 3838
Two-hybrid Homo sapiens
13 RCHY1  
Two-hybrid Homo sapiens
14 UACA 55075
Affinity Capture-MS Homo sapiens
15 TRIM25 7706
Affinity Capture-MS Homo sapiens
16 GRB10 2887
Affinity Capture-MS Homo sapiens
17 RDX 5962
Affinity Capture-MS Homo sapiens
18 RAB7A 7879
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
19 TRIOBP 11078
Affinity Capture-MS Homo sapiens
20 VPS39 23339
Reconstituted Complex Homo sapiens
21 SNF8 11267
Reconstituted Complex Homo sapiens
22 VPS18 57617
Reconstituted Complex Homo sapiens
23 OSBPL1A 114876
Affinity Capture-MS Homo sapiens
24 VPS11 55823
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RILP is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Immune System TAS Reactome
MHC class II antigen presentation TAS Reactome





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