Gene description for Smpdl3b
Gene name sphingomyelin phosphodiesterase, acid-like 3B
Gene symbol Smpdl3b
Other names/aliases 1110054A24Rik
AU045240
Asml3b
Species Mus musculus
 Database cross references - Smpdl3b
ExoCarta ExoCarta_100340
Entrez Gene 100340
UniProt P58242  
 Smpdl3b identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Smpdl3b
Molecular Function
    sphingomyelin phosphodiesterase activity GO:0004767 IEA
    cGMP-inhibited cyclic-nucleotide phosphodiesterase activity GO:0004119 IEA
    inositol phosphorylceramide phospholipase activity GO:0052713 IEA
    molecular_function GO:0003674 ND
    hydrolase activity, acting on glycosyl bonds GO:0016798 IEA
    mannosyl-diinositol phosphorylceramide phospholipase activity GO:0052715 IEA
    hydrolase activity GO:0016787 IEA
    inositol phosphosphingolipid phospholipase activity GO:0052712 IEA
    7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity GO:0044688 IEA
    photoreceptor cyclic-nucleotide phosphodiesterase activity GO:0004120 IEA
    3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 IEA
    calmodulin-dependent cyclic-nucleotide phosphodiesterase activity GO:0004117 IEA
    cyclic-nucleotide phosphodiesterase activity GO:0004112 IEA
    mannosyl-inositol phosphorylceramide phospholipase activity GO:0052714 IEA
    cGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118 IEA
Biological Process
    sphingomyelin catabolic process GO:0006685 IEA
    metabolic process GO:0008152 IEA
    biological_process GO:0008150 ND
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Smpdl3b in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Smpdl3b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Smpdl3b is involved
No pathways found





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