|
 Gene description for Akr1c18 |
| Gene name |
aldo-keto reductase family 1, member C18 |
| Gene symbol |
Akr1c18 |
| Other names/aliases |
AW146047 |
| Species |
Mus musculus |
| Database cross references - Akr1c18 |
| ExoCarta |
ExoCarta_105349 |
| Vesiclepedia |
VP_105349 |
| Entrez Gene |
105349 |
| UniProt |
Q8K023
|
| Akr1c18 identified in exosomes derived from the following tissue/cell type |
|
Colon cancer cells
|
37309723
|
|
T-cell lymphoma cells
|
37309723
|
| Gene ontology annotations for Akr1c18 |
| Molecular Function |
| |
versicolorin reductase activity |
GO:0042469 |
IEA |
|
| |
alditol:NADP+ 1-oxidoreductase activity |
GO:0004032 |
ISO |
|
| |
chloral hydrate dehydrogenase activity |
GO:0018447 |
IEA |
|
| |
retinal dehydrogenase activity |
GO:0001758 |
ISO |
|
| |
cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity |
GO:0034817 |
IEA |
|
| |
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
GO:0016655 |
ISO |
|
| |
hydroxymethylmethylsilanediol oxidase activity |
GO:0018448 |
IEA |
|
| |
phenanthrene 9,10-monooxygenase activity |
GO:0018636 |
ISO |
|
| |
2,4,4-trimethyl-1-pentanol dehydrogenase activity |
GO:0034863 |
IEA |
|
| |
androsterone dehydrogenase activity |
GO:0047023 |
ISO |
|
| |
geranylgeranyl reductase activity |
GO:0045550 |
ISO |
|
| |
2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity |
GO:0034778 |
IEA |
|
| |
pinocarveol dehydrogenase activity |
GO:0018446 |
IEA |
|
| |
3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity |
GO:0034918 |
IEA |
|
| |
2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity |
GO:0034868 |
IEA |
|
| |
ketosteroid monooxygenase activity |
GO:0047086 |
ISO |
|
| |
3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity |
GO:0034582 |
IEA |
|
| |
dihydrotestosterone 17-beta-dehydrogenase activity |
GO:0035410 |
ISO |
|
| |
oxidoreductase activity |
GO:0016491 |
IEA |
|
| |
cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity |
GO:0034522 |
IEA |
|
| |
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity |
GO:0047006 |
ISO |
|
| |
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity |
GO:0047020 |
ISO |
|
| |
retinol dehydrogenase activity |
GO:0004745 |
ISO |
|
| |
ketoreductase activity |
GO:0045703 |
ISO |
|
| |
3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity |
GO:0034944 |
IEA |
|
| |
citronellol dehydrogenase activity |
GO:0034821 |
IEA |
|
| |
naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity |
GO:0034847 |
IEA |
|
| |
myrtenol dehydrogenase activity |
GO:0018450 |
IEA |
|
| |
1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity |
GO:0034871 |
IEA |
|
| |
delta4-3-oxosteroid 5beta-reductase activity |
GO:0047787 |
ISO |
|
| |
endosulfan diol dehydrogenase activity |
GO:0034891 |
IEA |
|
| |
endosulfan hydroxyether dehydrogenase activity |
GO:0034901 |
IEA |
|
| |
1-phenylethanol dehydrogenase activity |
GO:0018449 |
IEA |
|
| Biological Process |
| |
doxorubicin metabolic process |
GO:0044598 |
ISO |
|
| |
positive regulation of protein kinase B signaling |
GO:0051897 |
ISO |
|
| |
cellular response to reactive oxygen species |
GO:0034614 |
ISO |
|
| |
G-protein coupled receptor signaling pathway |
GO:0007186 |
ISO |
|
| |
cellular response to prostaglandin stimulus |
GO:0071379 |
ISO |
|
| |
negative regulation of retinoic acid biosynthetic process |
GO:1900053 |
ISO |
|
| |
positive regulation of cell proliferation |
GO:0008284 |
ISO |
|
| |
oxidation-reduction process |
GO:0055114 |
ISO |
|
| |
positive regulation of endothelial cell apoptotic process |
GO:2000353 |
ISO |
|
| |
progesterone metabolic process |
GO:0042448 |
ISO |
|
| |
retinal metabolic process |
GO:0042574 |
ISO |
|
| |
progesterone catabolic process |
GO:0006709 |
IMP |
|
| |
regulation of steroid biosynthetic process |
GO:0050810 |
ISO |
|
| |
farnesol catabolic process |
GO:0016488 |
ISO |
|
| |
protein import into nucleus, translocation |
GO:0000060 |
ISO |
|
| |
cellular response to prostaglandin D stimulus |
GO:0071799 |
ISO |
|
| |
testosterone biosynthetic process |
GO:0061370 |
ISO |
|
| |
cellular response to calcium ion |
GO:0071277 |
ISO |
|
| |
positive regulation of reactive oxygen species metabolic process |
GO:2000379 |
ISO |
|
| |
regulation of retinoic acid receptor signaling pathway |
GO:0048385 |
ISO |
|
| |
cellular response to corticosteroid stimulus |
GO:0071384 |
ISO |
|
| |
daunorubicin metabolic process |
GO:0044597 |
ISO |
|
| |
positive regulation of cell death |
GO:0010942 |
ISO |
|
| |
parturition |
GO:0007567 |
IMP |
|
| |
regulation of testosterone biosynthetic process |
GO:2000224 |
ISO |
|
| |
cellular response to cadmium ion |
GO:0071276 |
ISO |
|
| |
cellular response to jasmonic acid stimulus |
GO:0071395 |
ISO |
|
| Subcellular Localization |
| |
extracellular exosome |
GO:0070062 |
ISO |
|
| |
cytoplasm |
GO:0005737 |
ISO |
|
| |
intracellular |
GO:0005622 |
ISO |
|
| |
cytosol |
GO:0005829 |
ISO |
|
| |
nucleus |
GO:0005634 |
ISO |
|
|
| Experiment description of studies that identified Akr1c18 in exosomes |
| 1 |
| Experiment ID |
907 |
| MISEV standards |
|
✔
EM
|
EV Biophysical techniques |
|
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
|
EV Enriched markers |
|
✔
HSPA5
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
Protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
37309723
|
| Organism |
Mus musculus |
| Experiment description |
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells |
| Authors |
Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S. |
| Journal name |
Proteomics
|
| Publication year |
2023 |
| Sample |
Colon cancer cells |
| Sample name |
C26 |
| Isolation/purification methods |
Differential centrifugation
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectrometry |
|
|
| 2 |
| Experiment ID |
908 |
| MISEV standards |
|
✔
EM
|
EV Biophysical techniques |
|
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
|
EV Enriched markers |
|
✔
HSPA5
|
EV Negative markers |
|
✔
NTA
|
EV Particle analysis
|
|
| Identified molecule |
Protein
|
| Identification method |
Mass spectrometry
|
| PubMed ID |
37309723
|
| Organism |
Mus musculus |
| Experiment description |
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells |
| Authors |
Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S. |
| Journal name |
Proteomics
|
| Publication year |
2023 |
| Sample |
T-cell lymphoma cells |
| Sample name |
EL4 |
| Isolation/purification methods |
Differential centrifugation
Ultracentrifugation |
| Flotation density |
-
|
| Molecules identified in the study |
Protein |
| Methods used in the study |
Western blotting
Mass spectrometry |
|
|
| Protein-protein interactions for Akr1c18 |
| |
Protein Interactor |
ExoCarta ID |
Identification method |
PubMed |
Species |
|
No interactions are found.
|
|
| Pathways in which Akr1c18 is involved |
|
|
|
