Gene description for SLC35D2
Gene name solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
Gene symbol SLC35D2
Other names/aliases HFRC1
SQV7L
UGTrel8
hfrc
Species Homo sapiens
 Database cross references - SLC35D2
ExoCarta ExoCarta_11046
Entrez Gene 11046
HGNC 20799
MIM 609182
UniProt Q76EJ3  
 SLC35D2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for SLC35D2
Molecular Function
    pyrimidine nucleotide-sugar transmembrane transporter activity GO:0015165 IBA
    nucleotide-sugar transmembrane transporter activity GO:0005338 NAS
    antiporter activity GO:0015297 IBA
Biological Process
    biological_process GO:0008150 ND
    pyrimidine nucleotide-sugar transmembrane transport GO:0090481 IBA
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    small molecule metabolic process GO:0044281 TAS
    transmembrane transport GO:0055085 TAS
    carbohydrate transport GO:0008643 IEA
    keratan sulfate metabolic process GO:0042339 TAS
    carbohydrate metabolic process GO:0005975 TAS
    keratan sulfate biosynthetic process GO:0018146 TAS
    anion transmembrane transport GO:0098656 IBA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    cellular_component GO:0005575 ND
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLC35D2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SLC35D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC35D2 is involved
PathwayEvidenceSource
HS-GAG biosynthesis TAS Reactome
Keratan sulfate biosynthesis TAS Reactome
Transport of nucleotide sugars TAS Reactome





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