Gene description for GPR176
Gene name G protein-coupled receptor 176
Gene symbol GPR176
Other names/aliases HB-954
Species Homo sapiens
 Database cross references - GPR176
ExoCarta ExoCarta_11245
Entrez Gene 11245
HGNC 32370
MIM 612183
UniProt Q14439  
 GPR176 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for GPR176
Molecular Function
    G-protein coupled receptor activity GO:0004930 IEA
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    synaptic transmission GO:0007268 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified GPR176 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for GPR176
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GPR176 is involved
No pathways found





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