Gene description for Acaa1a
Gene name acetyl-Coenzyme A acyltransferase 1A
Gene symbol Acaa1a
Other names/aliases Acaa
Acaa1
D9Ertd25e
PTL
Species Mus musculus
 Database cross references - Acaa1a
ExoCarta ExoCarta_113868
Entrez Gene 113868
UniProt Q921H8  
 Acaa1a identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Acaa1a
Molecular Function
    acetyl-CoA C-acyltransferase activity GO:0003988 IEA
    transferase activity, transferring acyl groups GO:0016746 IEA
    palmitoyl-CoA oxidase activity GO:0016401 ISO
    acetyl-CoA C-acetyltransferase activity GO:0003985 TAS
    transferase activity GO:0016740 IEA
    transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747 IEA
    catalytic activity GO:0003824 IEA
Biological Process
    fatty acid beta-oxidation GO:0006635 ISO
    fatty acid metabolic process GO:0006631 TAS
    very long-chain fatty acid metabolic process GO:0000038 ISO
    metabolic process GO:0008152 IEA
    lipid metabolic process GO:0006629 IEA
    bile acid metabolic process GO:0008206 ISO
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISO
    peroxisome GO:0005777 TAS
    mitochondrion GO:0005739 IDA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Acaa1a in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Acaa1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acaa1a is involved
PathwayEvidenceSource
alpha-linolenic acid (ALA) metabolism IEA Reactome
Beta-oxidation of very long chain fatty acids IEA Reactome





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