Gene description for Pafah1b3
Gene name platelet-activating factor acetylhydrolase 1b, catalytic subunit 3
Gene symbol Pafah1b3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pafah1b3
ExoCarta ExoCarta_114113
Entrez Gene 114113
UniProt O35263  
 Pafah1b3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Pafah1b3
Molecular Function
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 IEA
    identical protein binding GO:0042802 ISO
    platelet-activating factor acetyltransferase activity GO:0047179 TAS
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    brain development GO:0007420 IEP
    spermatogenesis GO:0007283 ISO
    lipid catabolic process GO:0016042 IEA
Subcellular Localization
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Pafah1b3 in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Pafah1b3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pafah1b3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here