Gene description for Chrnb1
Gene name cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Gene symbol Chrnb1
Other names/aliases Achr-2
Acrb
Species Mus musculus
 Database cross references - Chrnb1
ExoCarta ExoCarta_11443
Entrez Gene 11443
UniProt P09690  
 Chrnb1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Chrnb1
Molecular Function
    ion channel activity GO:0005216 IEA
    protein binding GO:0005515 IPI
    ligand-gated ion channel activity GO:0015276 ISO
    acetylcholine receptor activity GO:0015464 ISO
    extracellular ligand-gated ion channel activity GO:0005230 IEA
    acetylcholine binding GO:0042166 IMP
    channel activity GO:0015267 ISO
    acetylcholine-activated cation-selective channel activity GO:0004889 ISO
Biological Process
    neurological system process GO:0050877 ISO
    transmembrane transport GO:0055085 ISO
    ion transmembrane transport GO:0034220 ISO
    synaptic transmission, cholinergic GO:0007271 ISO
    transport GO:0006810 IEA
    signal transduction GO:0007165 ISO
    ion transport GO:0006811 IEA
    skeletal muscle contraction GO:0003009 ISO
    neuromuscular synaptic transmission GO:0007274 ISO
    regulation of membrane potential GO:0042391 IGI
    muscle contraction GO:0006936 ISO
    behavioral response to nicotine GO:0035095 ISO
    cation transport GO:0006812 ISO
    postsynaptic membrane organization GO:0001941 ISO
    cation transmembrane transport GO:0098655 ISO
    muscle fiber development GO:0048747 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    postsynaptic membrane GO:0045211 IEA
    plasma membrane GO:0005886 IDA
    acetylcholine-gated channel complex GO:0005892 ISO
    synapse GO:0045202 ISO
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Chrnb1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Chrnb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Chrnb1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here