Gene description for Impa2
Gene name inositol (myo)-1(or 4)-monophosphatase 2
Gene symbol Impa2
Other names/aliases 2210415D20Rik
AI326924
AW259601
Species Mus musculus
 Database cross references - Impa2
ExoCarta ExoCarta_114663
Vesiclepedia VP_114663
Entrez Gene 114663
UniProt Q91UZ5  
 Impa2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Impa2
Molecular Function
    inositol monophosphate 3-phosphatase activity GO:0052832 IEA
    inositol monophosphate phosphatase activity GO:0052834 IEA
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
    protein homodimerization activity GO:0042803 ISO
    inositol monophosphate 1-phosphatase activity GO:0008934 ISO
    inositol monophosphate 4-phosphatase activity GO:0052833 IEA
Biological Process
    dephosphorylation GO:0016311 ISA
    inositol metabolic process GO:0006020 TAS
    inositol phosphate dephosphorylation GO:0046855 ISO
    phosphatidylinositol phosphorylation GO:0046854 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Impa2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Impa2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Impa2 is involved
PathwayEvidenceSource
Synthesis of IP2, IP, and Ins in the cytosol IEA Reactome





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