Gene description for Atp1b3
Gene name ATPase, Na+/K+ transporting, beta 3 polypeptide
Gene symbol Atp1b3
Other names/aliases AA409958
AI664000
AW212096
Species Mus musculus
 Database cross references - Atp1b3
ExoCarta ExoCarta_11933
Entrez Gene 11933
UniProt P97370  
 Atp1b3 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Atp1b3
Molecular Function
    ATPase binding GO:0051117 ISO
    protein binding GO:0005515 IPI
    ATPase activator activity GO:0001671 ISO
    sodium:potassium-exchanging ATPase activity GO:0005391 ISO
Biological Process
    positive regulation of sodium ion export from cell GO:1903278 ISO
    membrane repolarization GO:0086009 ISO
    positive regulation of ATPase activity GO:0032781 ISO
    ion transport GO:0006811 IEA
    cellular potassium ion homeostasis GO:0030007 ISO
    transport GO:0006810 IEA
    potassium ion import GO:0010107 ISO
    cellular sodium ion homeostasis GO:0006883 ISO
    sodium ion export from cell GO:0036376 ISO
    positive regulation of potassium ion transmembrane transporter activity GO:1901018 ISO
    sodium ion transport GO:0006814 ISO
    protein localization to plasma membrane GO:0072659 ISO
    positive regulation of potassium ion import GO:1903288 ISO
    protein stabilization GO:0050821 ISO
    potassium ion transport GO:0006813 ISO
    metal ion transport GO:0030001 ISO
Subcellular Localization
    caveola GO:0005901 ISO
    sodium:potassium-exchanging ATPase complex GO:0005890 ISO
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Atp1b3 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Atp1b3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp1b3 is involved
PathwayEvidenceSource
Basigin interactions IEA Reactome
Ion transport by P-type ATPases IEA Reactome





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