Gene description for Slc7a1
Gene name solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Gene symbol Slc7a1
Other names/aliases 4831426K01Rik
AI447493
Atrc-1
Atrc1
Cat1
Rec-1
Rev-1
mCAT-1
Species Mus musculus
 Database cross references - Slc7a1
ExoCarta ExoCarta_11987
Entrez Gene 11987
UniProt Q09143  
 Slc7a1 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Slc7a1
Molecular Function
    arginine transmembrane transporter activity GO:0015181 ISO
    antiporter activity GO:0015297 IBA
    L-lysine transmembrane transporter activity GO:0015189 IBA
    amino acid transmembrane transporter activity GO:0015171 IEA
    L-ornithine transmembrane transporter activity GO:0000064 IBA
Biological Process
    regulation of TOR signaling GO:0032006 ISO
    transport GO:0006810 IEA
    L-lysine transmembrane transport GO:1903401 IBA
    amino acid transport GO:0006865 IEA
    L-arginine import across plasma membrane GO:0097638 IBA
    amino acid transmembrane transport GO:0003333 IEA
    arginine transport GO:0015809 ISO
    L-ornithine transmembrane transport GO:1903352 IBA
    arginine transmembrane transport GO:1903826 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    integral component of plasma membrane GO:0005887 IBA
    integral component of membrane GO:0016021 IC
 Experiment description of studies that identified Slc7a1 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc7a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc7a1 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane IEA Reactome





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