Gene description for Ctss
Gene name cathepsin S
Gene symbol Ctss
Other names/aliases -
Species Mus musculus
 Database cross references - Ctss
ExoCarta ExoCarta_13040
Entrez Gene 13040
UniProt O70370  
 Ctss identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Ctss
Molecular Function
    fibronectin binding GO:0001968 ISO
    laminin binding GO:0043236 ISO
    collagen binding GO:0005518 ISO
    hydrolase activity GO:0016787 IEA
    peptidase activity GO:0008233 IDA
    cysteine-type peptidase activity GO:0008234 ISO
    proteoglycan binding GO:0043394 ISO
    cysteine-type endopeptidase activity GO:0004197 ISO
Biological Process
    collagen catabolic process GO:0030574 ISO
    proteolysis GO:0006508 ISO
    regulation of sensory perception of pain GO:0051930 ISO
    positive regulation of inflammatory response GO:0050729 IGI
    protein processing GO:0016485 ISO
    response to acidic pH GO:0010447 ISO
    immune response GO:0006955 IBA
    antigen processing and presentation GO:0019882 IBA
    bone resorption GO:0045453 ISO
    antigen processing and presentation of peptide antigen GO:0048002 ISO
    basement membrane disassembly GO:0034769 ISO
    positive regulation of cation channel activity GO:2001259 ISO
    proteolysis involved in cellular protein catabolic process GO:0051603 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    lysosome GO:0005764 ISO
    membrane GO:0016020 IDA
 Experiment description of studies that identified Ctss in exosomes
1
Experiment ID 14
ISEV standards
EM
EV Biophysical techniques
RAB7|RAB11
EV Cytosolic markers
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Ctss
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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