Gene description for Apoa5
Gene name apolipoprotein A-V
Gene symbol Apoa5
Other names/aliases apo-AV
apoA-V
Species Rattus norvegicus
 Database cross references - Apoa5
ExoCarta ExoCarta_140638
Entrez Gene 140638
UniProt Q9QUH3  
 Apoa5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Apoa5
Molecular Function
    lipid binding GO:0008289 ISO
    cholesterol transporter activity GO:0017127 IBA
    enzyme binding GO:0019899 ISO
    phosphatidylcholine binding GO:0031210 ISO
    phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IBA
    lipoprotein particle receptor binding GO:0070325 ISO
    molecular_function GO:0003674 ND
    lipoprotein lipase activator activity GO:0060230 ISO
    lipase binding GO:0035473 ISO
    lipase activator activity GO:0060229 ISO
    phospholipid binding GO:0005543 ISO
    enzyme activator activity GO:0008047 ISO
    cholesterol binding GO:0015485 IBA
    low-density lipoprotein particle receptor binding GO:0050750 ISO
    heparin binding GO:0008201 ISO
Biological Process
    positive regulation of very-low-density lipoprotein particle remodeling GO:0010902 ISO
    triglyceride metabolic process GO:0006641 ISO
    high-density lipoprotein particle assembly GO:0034380 IBA
    triglyceride catabolic process GO:0019433 ISO
    lipid transport GO:0006869 ISO
    phosphatidylcholine metabolic process GO:0046470 IBA
    response to hormone GO:0009725 IEP
    organ regeneration GO:0031100 IEP
    very-low-density lipoprotein particle remodeling GO:0034372 IBA
    regulation of intestinal cholesterol absorption GO:0030300 IBA
    cholesterol biosynthetic process GO:0006695 IBA
    cholesterol efflux GO:0033344 IBA
    positive regulation of fatty acid biosynthetic process GO:0045723 ISO
    positive regulation of cholesterol esterification GO:0010873 IBA
    phospholipid efflux GO:0033700 IBA
    acylglycerol homeostasis GO:0055090 ISO
    positive regulation of triglyceride catabolic process GO:0010898 ISO
    triglyceride homeostasis GO:0070328 ISO
    cholesterol homeostasis GO:0042632 ISO
    positive regulation of lipoprotein lipase activity GO:0051006 ISO
    tissue regeneration GO:0042246 ISO
    lipoprotein metabolic process GO:0042157 IBA
    positive regulation of lipid catabolic process GO:0050996 ISO
    triglyceride-rich lipoprotein particle remodeling GO:0034370 ISO
    reverse cholesterol transport GO:0043691 IBA
    neuron projection regeneration GO:0031102 IBA
Subcellular Localization
    low-density lipoprotein particle GO:0034362 ISO
    extracellular region GO:0005576 ISO
    chylomicron GO:0042627 ISO
    extracellular space GO:0005615 ISO
    very-low-density lipoprotein particle GO:0034361 ISO
    blood microparticle GO:0072562 IBA
    high-density lipoprotein particle GO:0034364 ISO
 Experiment description of studies that identified Apoa5 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Apoa5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Apoa5 is involved
PathwayEvidenceSource
Chylomicron-mediated lipid transport IEA Reactome





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