Gene description for Fscn1
Gene name fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
Gene symbol Fscn1
Other names/aliases AI663989
Species Mus musculus
 Database cross references - Fscn1
ExoCarta ExoCarta_14086
Entrez Gene 14086
UniProt Q61553  
 Fscn1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Fscn1
Molecular Function
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 ISO
    protein binding, bridging GO:0030674 IEA
    drug binding GO:0008144 ISO
    actin binding GO:0003779 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    cell migration GO:0016477 ISO
    actin cytoskeleton organization GO:0030036 ISO
    actin filament bundle assembly GO:0051017 ISO
    cell motility GO:0048870 ISO
    actin filament organization GO:0007015 IEA
Subcellular Localization
    stress fiber GO:0001725 ISO
    cytoskeleton GO:0005856 IEA
    cell junction GO:0030054 IEA
    growth cone GO:0030426 ISO
    plasma membrane GO:0005886 ISO
    actin cytoskeleton GO:0015629 ISO
    myelin sheath GO:0043209 IDA
    cytoplasm GO:0005737 ISO
    dendrite GO:0030425 ISO
    ruffle GO:0001726 ISO
    lamellipodium GO:0030027 ISO
    cell projection GO:0042995 IEA
    invadopodium GO:0071437 ISO
    microvillus GO:0005902 ISO
    extracellular exosome GO:0070062 ISO
    filopodium GO:0030175 ISO
 Experiment description of studies that identified Fscn1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fscn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fscn1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here