Gene description for Ganab
Gene name alpha glucosidase 2 alpha neutral subunit
Gene symbol Ganab
Other names/aliases AU042638
G2an
GluII
mKIAA0088
Species Mus musculus
 Database cross references - Ganab
ExoCarta ExoCarta_14376
Entrez Gene 14376
UniProt Q8BHN3  
 Ganab identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Pancreatic cells 19351151    
 Gene ontology annotations for Ganab
Molecular Function
    protein binding GO:0005515 IPI
    glucan 1,3-alpha-glucosidase activity GO:0033919 IEA
    hydrolase activity, acting on glycosyl bonds GO:0016798 IEA
    carbohydrate binding GO:0030246 IEA
    poly(A) RNA binding GO:0044822 ISO
    hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 IEA
    hydrolase activity GO:0016787 IEA
    glucosidase activity GO:0015926 ISA
    catalytic activity GO:0003824 IEA
Biological Process
    carbohydrate metabolic process GO:0005975 IEA
    N-glycan processing GO:0006491 TAS
    metabolic process GO:0008152 IEA
Subcellular Localization
    glucosidase II complex GO:0017177 IPI
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    Golgi apparatus GO:0005794 IEA
    endoplasmic reticulum GO:0005783 TAS
 Experiment description of studies that identified Ganab in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ganab
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ganab is involved
PathwayEvidenceSource
Calnexin/calreticulin cycle IEA Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle IEA Reactome





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