Gene description for Got1
Gene name glutamic-oxaloacetic transaminase 1, soluble
Gene symbol Got1
Other names/aliases AI789014
Got-1
cAspAT
cCAT
Species Mus musculus
 Database cross references - Got1
ExoCarta ExoCarta_14718
Entrez Gene 14718
UniProt P05201  
 Got1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Got1
Molecular Function
    transferase activity GO:0016740 IEA
    transaminase activity GO:0008483 IEA
    L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069 ISO
    L-cysteine:2-oxoglutarate aminotransferase activity GO:0047801 ISO
    L-phenylalanine:2-oxoglutarate aminotransferase activity GO:0080130 IEA
    pyridoxal phosphate binding GO:0030170 IEA
    carboxylic acid binding GO:0031406 ISO
    catalytic activity GO:0003824 IEA
    phosphatidylserine decarboxylase activity GO:0004609 IDA
Biological Process
    glutamate catabolic process to 2-oxoglutarate GO:0019551 IDA
    dicarboxylic acid metabolic process GO:0043648 ISO
    Notch signaling pathway GO:0007219 IDA
    glycerol biosynthetic process GO:0006114 ISO
    cellular amino acid biosynthetic process GO:0008652 IEA
    fatty acid homeostasis GO:0055089 IDA
    aspartate biosynthetic process GO:0006532 IDA
    glutamate catabolic process to aspartate GO:0019550 IDA
    cellular amino acid metabolic process GO:0006520 IEA
    oxaloacetate metabolic process GO:0006107 IDA
    biosynthetic process GO:0009058 IEA
    aspartate metabolic process GO:0006531 ISO
    aspartate catabolic process GO:0006533 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    axon terminus GO:0043679 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 IDA
    lysosome GO:0005764 ISO
 Experiment description of studies that identified Got1 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Got1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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