Gene description for Coro1a
Gene name coronin, actin binding protein 1A
Gene symbol Coro1a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Coro1a
ExoCarta ExoCarta_155151
Entrez Gene 155151
UniProt Q91ZN1  
 Coro1a identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Coro1a
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    actin filament binding GO:0051015 ISO
    actin monomer binding GO:0003785 ISO
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    cytoskeletal protein binding GO:0008092 ISO
    actin binding GO:0003779 ISO
    molecular_function GO:0003674 ND
    protein C-terminus binding GO:0008022 ISO
    protein homodimerization activity GO:0042803 ISO
    myosin heavy chain binding GO:0032036 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    phagocytosis GO:0006909 ISO
    regulation of cell shape GO:0008360 ISO
    response to cytokine GO:0034097 ISO
    negative regulation of neuron apoptotic process GO:0043524 ISO
    cell-substrate adhesion GO:0031589 ISO
    positive regulation of T cell activation GO:0050870 ISO
    actin filament organization GO:0007015 ISO
    regulation of actin cytoskeleton organization GO:0032956 ISO
    biological_process GO:0008150 ND
    negative regulation of actin nucleation GO:0051126 ISO
    cellular response to interleukin-4 GO:0071353 ISO
    calcium ion transport GO:0006816 ISO
    positive regulation of cell migration GO:0030335 ISO
    early endosome to recycling endosome transport GO:0061502 ISO
    cell migration GO:0016477 ISO
    nerve growth factor signaling pathway GO:0038180 ISO
    regulation of actin filament polymerization GO:0030833 ISO
    immunological synapse formation GO:0001771 ISO
    leukocyte chemotaxis GO:0030595 ISO
    natural killer cell degranulation GO:0043320 ISO
    negative regulation of vesicle fusion GO:0031339 ISO
    uropod organization GO:0032796 ISO
    actin cytoskeleton organization GO:0030036 ISO
    T cell differentiation GO:0030217 NAS
    phagolysosome assembly GO:0001845 ISO
    T cell homeostasis GO:0043029 ISO
    regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO
    homeostasis of number of cells within a tissue GO:0048873 ISO
    positive regulation of T cell proliferation GO:0042102 ISO
    regulation of actin polymerization or depolymerization GO:0008064 ISO
    positive chemotaxis GO:0050918 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    early endosome GO:0005769 ISO
    cellular_component GO:0005575 ND
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 ISO
    phagocytic vesicle GO:0045335 ISO
    actin cytoskeleton GO:0015629 ISO
    axon GO:0030424 ISO
    protein complex GO:0043234 ISO
    intracellular GO:0005622 ISO
    immunological synapse GO:0001772 ISO
    phagocytic vesicle membrane GO:0030670 IEA
    nucleus GO:0005634 ISO
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 ISO
    actin filament GO:0005884 ISO
    cell leading edge GO:0031252 ISO
    cortical actin cytoskeleton GO:0030864 ISO
    cell GO:0005623 ISO
    lamellipodium GO:0030027 ISO
    phagocytic cup GO:0001891 ISO
 Experiment description of studies that identified Coro1a in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
5
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
6
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Coro1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Coro1a is involved
No pathways found





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