Gene description for Slc36a1
Gene name solute carrier family 36 (proton/amino acid symporter), member 1
Gene symbol Slc36a1
Other names/aliases Lyaat1
Species Rattus norvegicus
 Database cross references - Slc36a1
ExoCarta ExoCarta_155205
Entrez Gene 155205
UniProt Q924A5  
 Slc36a1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc36a1
Molecular Function
    L-proline transmembrane transporter activity GO:0015193 ISO
    hydrogen ion transmembrane transporter activity GO:0015078 IDA
    L-tyrosine transmembrane transporter activity GO:0005302 ISO
    L-alanine transmembrane transporter activity GO:0015180 ISO
    neutral amino acid transmembrane transporter activity GO:0015175 NAS
    glycine transmembrane transporter activity GO:0015187 ISO
    hydrogen:amino acid symporter activity GO:0005280 ISO
Biological Process
    proton transport GO:0015992 ISO
    L-alanine transport GO:0015808 ISO
    L-alpha-amino acid transmembrane transport GO:1902475 ISO
    hydrogen ion transmembrane transport GO:1902600 IDA
    neutral amino acid transport GO:0015804 IDA
    proline transport GO:0015824 ISO
    glycine transport GO:0015816 ISO
    proline transmembrane transport GO:0035524 ISO
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    lysosome GO:0005764 IDA
    integral component of membrane GO:0016021 IEA
    vacuolar membrane GO:0005774 IBA
    endoplasmic reticulum GO:0005783 ISO
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Slc36a1 in exosomes
1
Experiment ID 90
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc36a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc36a1 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane IEA Reactome
Proton-coupled neutral amino acid transporters IEA Reactome





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