Gene description for Itpa
Gene name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Gene symbol Itpa
Other names/aliases 2010016I08Rik
AU020102
Itp
Species Mus musculus
 Database cross references - Itpa
ExoCarta ExoCarta_16434
Entrez Gene 16434
UniProt Q9D892  
 Itpa identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Itpa
Molecular Function
    metal ion binding GO:0046872 IEA
    XTP diphosphatase activity GO:0036222 ISO
    nucleotide binding GO:0000166 IEA
    hydrolase activity GO:0016787 IEA
    ITP diphosphatase activity GO:0036220 ISO
    nucleoside-triphosphate diphosphatase activity GO:0047429 IDA
    dITP diphosphatase activity GO:0035870 ISO
Biological Process
    nucleoside triphosphate catabolic process GO:0009143 IEA
    chromosome organization GO:0051276 IMP
    nucleotide metabolic process GO:0009117 IEA
    ITP catabolic process GO:0006193 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Itpa in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Itpa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itpa is involved
PathwayEvidenceSource
Metabolism of nucleotides IEA Reactome





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