Gene description for Klf4
Gene name	Kruppel-like factor 4 (gut)
Gene symbol	Klf4
Other names/aliases	EZF Gklf Zie
Species	Mus musculus
Database cross references - Klf4
ExoCarta	ExoCarta_16600
Entrez Gene	16600
UniProt	Q60793
Klf4 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Klf4

Molecular Function     sequence-specific DNA binding GO:0043565 ISO     sequence-specific DNA binding transcription factor recruiting transcription factor activity GO:0001010 IDA     core promoter proximal region sequence-specific DNA binding GO:0000987 ISO     metal ion binding GO:0046872 IEA     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO     histone deacetylase binding GO:0042826 ISO     RNA polymerase II transcription factor binding GO:0001085 ISO     phosphatidylinositol 3-kinase regulator activity GO:0035014 ISO     beta-catenin binding GO:0008013 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 ISO     DNA binding GO:0003677 ISS     transcription regulatory region DNA binding GO:0044212 ISO     core promoter binding GO:0001047 IDA     transcription cofactor binding GO:0001221 ISO     transcription factor binding GO:0008134 IPI     nucleic acid binding GO:0003676 IEA     RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription GO:0001190 ISO     double-stranded DNA binding GO:0003690 ISO Biological Process     negative regulation of chemokine (C-X-C motif) ligand 2 production GO:2000342 ISO     regulation of transcription, DNA-templated GO:0006355 IEA     transcription from RNA polymerase II promoter GO:0006366 ISO     negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO     response to organic substance GO:0010033 IDA     negative regulation of interleukin-8 biosynthetic process GO:0045415 ISO     fat cell differentiation GO:0045444 IMP     negative regulation of heterotypic cell-cell adhesion GO:0034115 ISO     negative regulation of protein kinase B signaling GO:0051898 ISO     positive regulation of transcription, DNA-templated GO:0045893 IDA     positive regulation of telomerase activity GO:0051973 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO     transcription, DNA-templated GO:0006351 IEA     cellular response to laminar fluid shear stress GO:0071499 ISO     post-embryonic camera-type eye development GO:0031077 IMP     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO     cell differentiation GO:0030154 IMP     negative regulation of cell proliferation GO:0008285 IDA     response to retinoic acid GO:0032526 IDA     negative regulation of transcription, DNA-templated GO:0045892 NAS     post-embryonic hemopoiesis GO:0035166 ISO     epidermis morphogenesis GO:0048730 IMP     positive regulation of hemoglobin biosynthetic process GO:0046985 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO     negative regulation of smooth muscle cell proliferation GO:0048662 ISO     negative regulation of muscle hyperplasia GO:0014740 ISO     negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 ISO     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 ISO     regulation of transcription from RNA polymerase II promoter GO:0006357 IDA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO     stem cell maintenance GO:0019827 IDA     cellular response to growth factor stimulus GO:0071363 ISO     epidermal cell differentiation GO:0009913 IMP     positive regulation of protein metabolic process GO:0051247 ISO     regulation of phosphatidylinositol 3-kinase activity GO:0043551 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     negative regulation of response to cytokine stimulus GO:0060761 ISO     positive regulation of cellular protein metabolic process GO:0032270 ISO     canonical Wnt signaling pathway GO:0060070 IMP     regulation of cell differentiation GO:0045595 IDA     regulation of cell proliferation GO:0042127 IGI Subcellular Localization     nuclear chromatin GO:0000790 ISO     nuclear euchromatin GO:0005719 IDA     nucleus GO:0005634 NAS     chromatin GO:0000785 ISO     transcription factor complex GO:0005667 ISO     nucleoplasm GO:0005654 ISO     nuclear transcription factor complex GO:0044798 IDA