Gene description for Lasp1
Gene name LIM and SH3 protein 1
Gene symbol Lasp1
Other names/aliases AA408629
Def-4
SH3P6
Tg(Col1a1-lacZ)1Ngma
Species Mus musculus
 Database cross references - Lasp1
ExoCarta ExoCarta_16796
Vesiclepedia VP_16796
Entrez Gene 16796
UniProt Q61792  
 Lasp1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lasp1
Molecular Function
    ion transmembrane transporter activity GO:0015075 ISO
    actin filament binding GO:0051015 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    actin binding GO:0003779 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    transport GO:0006810 IEA
    ion transmembrane transport GO:0034220 ISO
    ion transport GO:0006811 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    cytoplasm GO:0005737 IDA
    cortical actin cytoskeleton GO:0030864 ISO
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Lasp1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lasp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lasp1 is involved
No pathways found





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