Gene description for Lpl
Gene name lipoprotein lipase
Gene symbol Lpl
Other names/aliases -
Species Mus musculus
 Database cross references - Lpl
ExoCarta ExoCarta_16956
Entrez Gene 16956
UniProt P11152  
 Lpl identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Microglia 16081791    
 Gene ontology annotations for Lpl
Molecular Function
    hydrolase activity GO:0016787 IEA
    triglyceride lipase activity GO:0004806 ISO
    heparin binding GO:0008201 ISO
    lipoprotein lipase activity GO:0004465 ISO
    apolipoprotein binding GO:0034185 ISO
    protein binding GO:0005515 IPI
    triglyceride binding GO:0017129 ISO
    receptor binding GO:0005102 ISO
    carboxylic ester hydrolase activity GO:0052689 IEA
Biological Process
    lipid metabolic process GO:0006629 IEA
    positive regulation of sequestering of triglyceride GO:0010890 ISO
    triglyceride catabolic process GO:0019433 ISO
    very-low-density lipoprotein particle remodeling GO:0034372 ISO
    fatty acid biosynthetic process GO:0006633 ISO
    positive regulation of cholesterol storage GO:0010886 ISO
    lipid catabolic process GO:0016042 ISO
    positive regulation of macrophage derived foam cell differentiation GO:0010744 IGI
    triglyceride biosynthetic process GO:0019432 ISO
    triglyceride homeostasis GO:0070328 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    cell surface GO:0009986 IDA
    extracellular space GO:0005615 ISO
    very-low-density lipoprotein particle GO:0034361 IEA
    anchored component of membrane GO:0031225 IEA
    plasma membrane GO:0005886 IEA
    extracellular region GO:0005576 IEA
    chylomicron GO:0042627 IEA
    extracellular matrix GO:0031012 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Lpl in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 14
ISEV standards
EM
EV Biophysical techniques
RAB7|RAB11
EV Cytosolic markers
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Lpl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lpl is involved
PathwayEvidenceSource
Chylomicron-mediated lipid transport IEA Reactome
Retinoid metabolism and transport IEA Reactome





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