Gene description for Gbp2
Gene name guanylate binding protein 2, interferon-inducible
Gene symbol Gbp2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gbp2
ExoCarta ExoCarta_171164
Entrez Gene 171164
UniProt Q63663  
 Gbp2 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Gbp2
Molecular Function
    GTP binding GO:0005525 IEA
    GTPase activity GO:0003924 IEA
Biological Process
    cellular response to interferon-beta GO:0035458 ISO
    defense response to protozoan GO:0042832 ISO
    defense response to Gram-positive bacterium GO:0050830 ISO
    adhesion of symbiont to host GO:0044406 ISO
    cellular response to interferon-gamma GO:0071346 ISO
    cellular response to lipopolysaccharide GO:0071222 ISO
    metabolic process GO:0008152 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 ISO
    Golgi membrane GO:0000139 IEA
    nucleus GO:0005634 IEA
    symbiont-containing vacuole membrane GO:0020005 ISO
 Experiment description of studies that identified Gbp2 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Gbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gbp2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here