Gene description for Mtf1
Gene name metal response element binding transcription factor 1
Gene symbol Mtf1
Other names/aliases MTF-1
Thyls
Species Mus musculus
 Database cross references - Mtf1
ExoCarta ExoCarta_17764
Entrez Gene 17764
UniProt Q07243  
 Mtf1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mtf1
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    histone acetyltransferase binding GO:0035035 IPI
    DNA binding GO:0003677 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IDA
    core promoter binding GO:0001047 ISO
    metal ion binding GO:0046872 IEA
    nucleic acid binding GO:0003676 IEA
Biological Process
    response to oxidative stress GO:0006979 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription from RNA polymerase II promoter GO:0006366 ISO
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    regulation of transcription from RNA polymerase II promoter GO:0006357 IEA
    transition metal ion homeostasis GO:0055076 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    response to cadmium ion GO:0046686 IMP
    transcription, DNA-templated GO:0006351 IEA
    response to metal ion GO:0010038 IEA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 IC
 Experiment description of studies that identified Mtf1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Mtf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mtf1 is involved
No pathways found





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