Gene description for Pla2g1b
Gene name phospholipase A2, group IB, pancreas
Gene symbol Pla2g1b
Other names/aliases Pla2a
Species Mus musculus
 Database cross references - Pla2g1b
ExoCarta ExoCarta_18778
Entrez Gene 18778
UniProt Q9Z0Y2  
 Pla2g1b identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Pla2g1b
Molecular Function
    calcium ion binding GO:0005509 ISO
    calcium-dependent phospholipase A2 activity GO:0047498 ISO
    receptor binding GO:0005102 ISO
    phospholipase A2 activity GO:0004623 ISO
    metal ion binding GO:0046872 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    fatty acid biosynthetic process GO:0006633 ISO
    defense response to Gram-positive bacterium GO:0050830 ISO
    phospholipid catabolic process GO:0009395 TAS
    innate immune response in mucosa GO:0002227 ISO
    multicellular organismal lipid catabolic process GO:0044240 ISO
    antibacterial humoral response GO:0019731 ISO
    phospholipid metabolic process GO:0006644 ISO
    positive regulation of DNA replication GO:0045740 ISO
    lipid metabolic process GO:0006629 IEA
    lipid catabolic process GO:0016042 IEA
    phosphatidylcholine metabolic process GO:0046470 ISO
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    secretory granule GO:0030141 ISO
 Experiment description of studies that identified Pla2g1b in exosomes
Experiment ID 89
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M.
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
 Protein-protein interactions for Pla2g1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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