Gene description for Rac2
Gene name RAS-related C3 botulinum substrate 2
Gene symbol Rac2
Other names/aliases AI323801
AI452260
Species Mus musculus
 Database cross references - Rac2
ExoCarta ExoCarta_19354
Entrez Gene 19354
UniProt Q05144  
 Rac2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rac2
Molecular Function
    GTPase activity GO:0003924 IDA
    nucleotide binding GO:0000166 IEA
    GTP binding GO:0005525 ISO
Biological Process
    regulation of cell-substrate adhesion GO:0010810 ISO
    positive regulation of neutrophil chemotaxis GO:0090023 ISO
    regulation of respiratory burst GO:0060263 ISO
    cell projection assembly GO:0030031 IDA
    actin cytoskeleton organization GO:0030036 ISO
    positive regulation of lamellipodium assembly GO:0010592 ISO
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    small GTPase mediated signal transduction GO:0007264 IEA
    positive regulation of cell proliferation GO:0008284 IMP
    bone resorption GO:0045453 ISO
    regulation of neutrophil migration GO:1902622 ISO
    actin filament organization GO:0007015 ISO
    chemotaxis GO:0006935 IDA
    lymphocyte aggregation GO:0071593 ISO
    G-protein coupled receptor signaling pathway GO:0007186 IGI
Subcellular Localization
    lamellipodium GO:0030027 ISO
    cytoplasm GO:0005737 IDA
    actin filament GO:0005884 ISO
    intracellular GO:0005622 IEA
    cytosol GO:0005829 ISO
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IDA
    nuclear envelope GO:0005635 IDA
 Experiment description of studies that identified Rac2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rac2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMAD4  
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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