Gene description for EGFR
Gene name	epidermal growth factor receptor
Gene symbol	EGFR
Other names/aliases	ERBB ERBB1 HER1 NISBD2 PIG61 mENA
Species	Homo sapiens
Database cross references - EGFR
ExoCarta	ExoCarta_1956
Entrez Gene	1956
HGNC	3236
MIM	131550
UniProt	P00533
EGFR identified in exosomes derived from the following tissue/cell type
Bladder cancer cells	20224111
Colorectal cancer cells	19837982
Colorectal cancer cells	22740476
Keratinocytes	19530224
Keratinocytes	19530224
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Nasopharyngeal carcinoma cells	21059916
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Pancreatic cancer cells	21763319
Pancreatic cancer cells	21763319
Pancreatic cancer cells	21763319
Pancreatic cancer cells	21763319
Pancreatic cancer cells	21763319
Prostate cancer cells	25844599
Prostate cancer cells	25844599
Serum	19109410
Thymus	23844026

Gene ontology annotations for EGFR

Molecular Function     actin filament binding GO:0051015 IDA     chromatin binding GO:0003682 IDA     epidermal growth factor-activated receptor activity GO:0005006 NAS     protein phosphatase binding GO:0019903 IPI     enzyme binding GO:0019899 IPI     double-stranded DNA binding GO:0003690 NAS     protein kinase binding GO:0019901 IEA     transmembrane signaling receptor activity GO:0004888 IDA     protein heterodimerization activity GO:0046982 IDA     receptor signaling protein tyrosine kinase activity GO:0004716 IEA     nitric-oxide synthase regulator activity GO:0030235 IDA     identical protein binding GO:0042802 IPI     integrin binding GO:0005178 IEA     ubiquitin protein ligase binding GO:0031625 IPI     protein binding GO:0005515 IPI     epidermal growth factor binding GO:0048408 IEA     glycoprotein binding GO:0001948 IEA     protein tyrosine kinase activity GO:0004713 TAS     transmembrane receptor protein tyrosine kinase activity GO:0004714 TAS     MAP kinase kinase kinase activity GO:0004709 NAS     ATP binding GO:0005524 IEA Biological Process     positive regulation of DNA replication GO:0045740 IDA     salivary gland morphogenesis GO:0007435 IEA     innate immune response GO:0045087 TAS     magnesium ion homeostasis GO:0010960 IEA     learning or memory GO:0007611 ISS     regulation of nitric-oxide synthase activity GO:0050999 IDA     positive regulation of phosphorylation GO:0042327 IDA     single organismal cell-cell adhesion GO:0016337 IMP     positive regulation of epithelial cell proliferation GO:0050679 IDA     positive regulation of inflammatory response GO:0050729 IEA     positive regulation of protein phosphorylation GO:0001934 IDA     negative regulation of apoptotic process GO:0043066 IMP     positive regulation of protein kinase B signaling GO:0051897 IMP     cellular response to dexamethasone stimulus GO:0071549 IEA     morphogenesis of an epithelial fold GO:0060571 IEA     positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA     response to UV-A GO:0070141 IDA     signal transduction GO:0007165 TAS     cellular response to amino acid stimulus GO:0071230 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     response to oxidative stress GO:0006979 IEA     activation of phospholipase C activity GO:0007202 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     diterpenoid metabolic process GO:0016101 IEA     cellular response to mechanical stimulus GO:0071260 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of superoxide anion generation GO:0032930 IEA     hair follicle development GO:0001942 IEA     positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 IDA     negative regulation of mitotic cell cycle GO:0045930 IEA     translation GO:0006412 IEA     axon guidance GO:0007411 TAS     liver development GO:0001889 IEA     cellular response to epidermal growth factor stimulus GO:0071364 ISS     positive regulation of vasodilation GO:0045909 IEA     cell surface receptor signaling pathway GO:0007166 IDA     MAPK cascade GO:0000165 NAS     negative regulation of protein catabolic process GO:0042177 IDA     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 TAS     positive regulation of cell migration GO:0030335 IMP     positive regulation of MAP kinase activity GO:0043406 IDA     digestive tract morphogenesis GO:0048546 IEA     positive regulation of cell proliferation GO:0008284 IDA     hydrogen peroxide metabolic process GO:0042743 IEA     activation of phospholipase A2 activity by calcium-mediated signaling GO:0043006 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     activation of MAPKK activity GO:0000186 IEA     peptidyl-tyrosine phosphorylation GO:0018108 TAS     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IMP     ovulation cycle GO:0042698 IEA     alkanesulfonate metabolic process GO:0019694 IEA     positive regulation of vasoconstriction GO:0045907 IEA     protein autophosphorylation GO:0046777 IMP     tongue development GO:0043586 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     embryonic placenta development GO:0001892 IEA     cerebral cortex cell migration GO:0021795 IEA     lung development GO:0030324 IEA     ossification GO:0001503 NAS     cell proliferation GO:0008283 IDA     response to hydroxyisoflavone GO:0033594 IEA     response to calcium ion GO:0051592 IEA     response to osmotic stress GO:0006970 IEA     response to stress GO:0006950 NAS     astrocyte activation GO:0048143 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     positive regulation of fibroblast proliferation GO:0048146 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     protein insertion into membrane GO:0051205 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     response to cobalamin GO:0033590 IEA     circadian rhythm GO:0007623 IEA     positive regulation of catenin import into nucleus GO:0035413 IMP     positive regulation of DNA repair GO:0045739 IDA     cellular response to estradiol stimulus GO:0071392 IDA     cellular response to drug GO:0035690 IEA Subcellular Localization     apical plasma membrane GO:0016324 IEA     AP-2 adaptor complex GO:0030122 TAS     plasma membrane GO:0005886 TAS     receptor complex GO:0043235 IDA     endosome GO:0005768 IDA     endosome membrane GO:0010008 IDA     Shc-EGFR complex GO:0070435 ISS     endoplasmic reticulum membrane GO:0005789 IEA     Golgi membrane GO:0000139 IEA     integral component of membrane GO:0016021 IEA     membrane raft GO:0045121 IDA     focal adhesion GO:0005925 IDA     nuclear membrane GO:0031965 IEA     nucleus GO:0005634 IDA     extracellular space GO:0005615 NAS     cytoplasm GO:0005737 IDA     perinuclear region of cytoplasm GO:0048471 IEA     membrane GO:0016020 IDA     basolateral plasma membrane GO:0016323 IDA     cell surface GO:0009986 IDA     multivesicular body, internal vesicle lumen GO:0097489 IDA     early endosome membrane GO:0031901 IDA